Rabbit Models for Studying Human Infectious Diseases

被引：3
作者：
Peng, Xuwen [1 ]
Knouse, John A. [1 ]
Hernon, Krista M. [1 ]
机构：
[1] Penn State Univ, Coll Med, Dept Comparat Med, Hershey, PA USA
来源：
COMPARATIVE MEDICINE | 2015年 / 65卷 / 06期
关键词：
HERPES-SIMPLEX-VIRUS; CELL LEUKEMIA-VIRUS; TREPONEMA-PARALUIS-CUNICULI; T-CELL; TRANSGENIC RABBIT; HUMAN-PAPILLOMAVIRUS; CONGENITAL-SYPHILIS; HIV-1; INFECTION; ANIMAL-MODELS; HTLV-I;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Using an appropriate animal model is crucial for mimicking human disease conditions, and various facets including genetics, anatomy, and pathophysiology should be considered before selecting a model. Rabbits (Oryctolagus cuniculus) are well known for their wide use in production of antibodies, eye research, atherosclerosis and other cardiovascular diseases. However, a systematic description of the rabbit as primary experimental models for the study of various human infectious diseases is unavailable. This review focuses on the human infectious diseases for which rabbits are considered a classic or highly appropriate model, including AIDS (caused by HIV1), adult T-cell leukemia-lymphoma (human T-lymphotropic virus type 1), papilloma or carcinoma (human papillomavirus), herpetic stromal keratitis (herpes simplex virus type 1), tuberculosis (Mycobacterium tuberculosis), and syphilis (Treponema pallidum). In addition, particular aspects of the husbandry and care of rabbits used in studies of human infectious diseases are described.
引用
收藏
页码：499 / 507
页数：9
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