Ciprofloxacin, lomefloxacin, or levofloxacin as treatment for chronic osteomyelitis

被引:53
作者
Greenberg, RN
Newman, MT
Shariaty, S
Pectol, RW
机构
[1] Univ Kentucky, Med Ctr, Dept Med, Lexington, KY 40536 USA
[2] Univ Kentucky, Med Ctr, Dept Orthoped Surg, Lexington, KY 40536 USA
关键词
D O I
10.1128/AAC.44.1.164-166.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed. Twenty-seven patients had documented infections with quinolone-sensitive organisms and received either lomefloxacin, levofloxacin, or ciprofloxacin. Levofloxacin was effective therapy for 9 of 15 (60%) patients. Lomefloxacin was effective therapy for five of seven (71%) patients, and ciprofloxacin was effective therapy for two of five patients (40%). Average follow-up was 11.8 months for patients who completed the course of therapy, and the average duration of therapy was 60.6 days. Grampositive bacteria were isolated from 18 patients, and 11 patients were cured. Oral fluoroquinolones can be safe, effective therapy if they are given for a prolonged course as treatment for infections caused by susceptible grampositive as well as gram-negative organisms and in combination with adequate surgical debridement.
引用
收藏
页码:164 / 166
页数:3
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