Electrochemiluminescence Imaging for Bioanalysis

被引：174

作者：

Zhang, Jingjing ^{[1
]}

Arbault, Stephane ^{[2
,3
]}

Sojic, Neso ^{[2
,3
]}

Jiang, Dechen ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China

[2] Univ Bordeaux, Bordeaux INP, Inst Mol Sci ISM, F-33607 Pessac, France

[3] Univ Bordeaux, CNRS, UMR 5255, F-33607 Pessac, France

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 12 | 2019年 / 12卷

基金：

中国国家自然科学基金;

关键词：

electrochemiluminescence imaging; spatial/temporal resolutions; multiplex bioassay; single cells/particles; coreactant pathway; bipolar electrochemistry; BIPOLAR ELECTRODE ARRAY; ELECTROGENERATED CHEMILUMINESCENCE; ACTIVE CHOLESTEROL; HYDROGEN-PEROXIDE; PLASMA-MEMBRANE; MICROWELL ARRAY; ORDERED ARRAY; SINGLE CELLS; LUMINOL; MICROSCOPY;

D O I：

10.1146/annurev-anchem-061318-115226

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Electrochemiluminescence (ECL) is a widely used analytical technique with the advantages of high sensitivity and low background signal. The recent and rapid development of electrochemical materials, luminophores, and optical elements significantly increases the ECL signals and, thus, ECL imaging with enhanced spatial and temporal resolutions is realized. Currently, ECL imaging is successfully applied to high-throughput bioanalysis and to visualize the distribution of molecules at single cells. Compared with other optical bioassays, no optical excitation is involved in imaging, so the approach avoids a background signal from illumination and increases the detection sensitivity. This review highlights some of the most exciting developments in this field, including the mechanisms, electrode designs, and the applications of ECL imaging in bioanalysis and at single cells and particles.

引用

页码：275 / 295

页数：21

共 92 条

[91] Electrogenerated Chemiluminescence Imaging of Electrocatalysis at a Single Au-Pt Janus Nanoparticle [J].