Is There Clinical Value to Prognostic Signatures in Early-Stage NSCLC?

被引：4

作者：

Bunn, Paul A., Jr. ^{[1
]}

Hirsch, Fred R. ^{[1
,2
]}

Aisner, Dara L. ^{[2
]}

机构：

[1] Univ Colorado Denver, Univ Colorado Canc Ctr, Dept Med, Div Med Oncol, Aurora, CO 80045 USA

[2] Univ Colorado Denver, Univ Colorado Canc Ctr, Dept Pathol, Aurora, CO 80045 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 07期

关键词：

CELL LUNG-CANCER; ADJUVANT CHEMOTHERAPY; PREDICT SURVIVAL; VALIDATION; ASSAY; RISK;

D O I：

10.1158/1078-0432.CCR-13-3387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

pAMPK and pmTOR favorably predicted outcome in early non-small cell lung cancer (NSCLC). The differences were small. Phosphoprotein lability makes routine clinical use and validation difficult. Protein immunohistochemistry is unlikely to be clinically useful, and numerous efforts to create predictive models to select resected patients for therapy have been unsuccessful. (C) 2014 AACR.

引用

页码：1727 / 1729

页数：3

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