Novel strategies for the formulation and processing of poorly water-soluble drugs

被引：121

作者：

Goeke, Katrin ^{[1
,6
]}

Lorenz, Thomas ^{[2
,6
]}

Repanas, Alexandros ^{[3
,6
]}

Schneider, Frederic ^{[4
,6
]}

Steiner, Denise ^{[5
,6
]}

Baumann, Knut ^{[4
,6
]}

Bunjes, Heike ^{[1
,6
]}

Dietzel, Andreas ^{[2
,6
]}

Finke, Jan H. ^{[5
,6
]}

Glasmacher, Birgit ^{[3
,6
]}

Kwade, Arno ^{[5
,6
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmazeut Technol, Mendelssohnstr 1, D-38106 Braunschweig, Germany

[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrotech, Alte Salzdahlumer Str 203, D-38124 Braunschweig, Germany

[3] Leibniz Univ Hannover, Inst Mehrphasenprozesse, Callinstr 36, D-30167 Hannover, Germany

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmazeut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany

[5] Tech Univ Carolo Wilhelmina Braunschweig, Inst Partikeltech, Volkmaroder Str 5, D-38104 Braunschweig, Germany

[6] Tech Univ Carolo Wilhelmina Braunschweig, Zentrum Pharmaverfahrenstech PVZ, Franz Liszt Str 35a, D-38106 Braunschweig, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2018年 / 126卷

关键词：

Solubility; Drug delivery systems; Colloidal lipid carriers; Drug nanosuspensions; Orodispersible films; Computational carrier selection; Microfluidics; Electrospinning; SOLID LIPID NANOPARTICLES; MOLECULAR-DYNAMICS; IN-VIVO; BIOPHARMACEUTICAL CLASSIFICATION; COMPUTATIONAL PREDICTION; ELECTROSPUN NANOFIBERS; ORODISPERSIBLE FILMS; CONTROLLED-RELEASE; ORGANIC-COMPOUNDS; ANTICANCER AGENT;

D O I：

10.1016/j.ejpb.2017.05.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：40 / 56

页数：17

共 204 条

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