Inhibitory effects of resveratrol on hypoxia-induced inflammation in 3T3-L1 adipocytes and macrophages

被引：13

作者：

Cullberg, Karina B. ^{[1
]}

Foldager, Casper B. ^{[2
]}

Lind, Martin ^{[2
]}

Richelsen, Bjorn ^{[1
]}

Pedersen, Steen B. ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Endocrinol & Intemal Med, MEA, THG, DK-8000 Aarhus, Denmark

[2] Aarhus Univ Hosp, Sports Trauma Clin & Orthopaed Res Lab, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF FUNCTIONAL FOODS | 2014年 / 7卷

关键词：

Sirtuins; Obesity; 3T3-L1; THP-1; Inflammation; Hypoxia; ADIPOSE-TISSUE HYPOXIA; ADIPOKINE EXPRESSION; INSULIN-RESISTANCE; LIPID-METABOLISM; OXYGEN-TENSION; GLUCOSE-UPTAKE; IN-VITRO; OBESITY; ADIPONECTIN; DYSFUNCTION;

D O I：

10.1016/j.jff.2014.02.015

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Resveratrol is a natural compound proposed to posses powerful anti-obesity effects. Hypoxia may be an underlying mechanism for adipose tissue dysfunction in obesity. We have previously shown that resveratrol mediates a reduction in hypoxia induced inflammation in whole adipose tissue, thus in this study we investigated whether hypoxia and resveratrol primarily affect adipocytes or the macrophages in the adipose tissue. Hypoxia induced a significant increase in the production of hypoxic key markers in 3T3-L1 adipocytes and THP-1 macrophages, and stimulated gene expression levels of inflammatory markers in macrophages with almost no effect in adipocytes. Resveratrol attenuated the hypoxia induced increase in gene expression levels. These results suggest that the hypoxia-induced inflammatory response in whole adipose tissue mainly is driven by resident macrophages. Moreover, the results suggest that resveratrol could have treatment potential by attenuating adipose tissue inflammation in obesity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：171 / 179

页数：9

共 44 条

[1] Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes [J].

Ahn, Jiyun ;

Lee, Hyunjung ;

Kim, Suna ;

Ha, Taeyoul .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 364 (04) :972-977

[2] Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women [J].

Alvehus, Malin ;

Simonyte, Kotryna ;

Andersson, Therese ;

Soderstrom, Ingegerd ;

Buren, Jonas ;

Rask, Eva ;

Mattsson, Cecilia ;

Olsson, Tommy .

CLINICAL ENDOCRINOLOGY, 2012, 77 (05) :684-690

[3] Functional food ingredients for the management of obesity and associated co-morbidities - A review [J].

Baboota, Ritesh K. ;

Bishnoi, Mahendra ;

Ambalam, Padma ;

Kondepudi, Kanthi Kiran ;

Sarma, Siddhartha M. ;

Boparai, Ravneet K. ;

Podili, Koteswaraiah .

JOURNAL OF FUNCTIONAL FOODS, 2013, 5 (03) :997-1012

[4] Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro [J].

Bastard, JP ;

Maachi, M ;

Van Nhieu, JT ;

Jardel, C ;

Bruckert, E ;

Grimaldi, A ;

Robert, JJ ;

Capeau, J ;

Hainque, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) :2084-2089

[5] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[6] Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[7] Adipose Tissue Dysfunction in Obesity [J].

Bluehre, M. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2009, 117 (06) :241-250

[8] Oxygen, a source of life and stress [J].

Brahimi-Horn, M. Christiane ;

Pouyssegur, Jacques .

FEBS LETTERS, 2007, 581 (19) :3582-3591

[9] Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes [J].

Chen, BY ;

Lam, KSL ;

Wang, Y ;

Wu, DH ;

Lam, MC ;

Shen, JG ;

Wong, LC ;

Hoo, RLC ;

Zhang, JL ;

Xu, AM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 341 (02) :549-556

[10] Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro [J].

Cullberg, Karina B. ;

Olholm, Jens ;

Paulsen, Soren K. ;

Foldager, Casper B. ;

Lind, Martin ;

Richelsen, Bjorn ;

Pedersen, Steen B. .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 49 (02) :251-257

← 1 2 3 4 5 →