Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy

被引：62

作者：

Pang, Yanyu ^{[1
]}

Hou, Xiaoyang ^{[1
]}

Yang, Chunsheng ^{[2
]}

Liu, Yanqun ^{[1
]}

Jiang, Guan ^{[1
]}

机构：

[1] Xuzhou Med Univ, Affiliated Hosp, Dept Dermatol, Xuzhou 221002, Peoples R China

[2] Xuzhou Med Univ, Peoples Hosp Huaian 2, Affiliated Huaian Hosp, Dept Dermatol, Huaian 223002, Peoples R China

来源：

MOLECULAR CANCER | 2018年 / 17卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Chimeric antigen receptor T cells; Hematological malignancies; Acute lymphoblastic leukemia; Solid tumors; Cytokine release syndrome; TUMOR-INFILTRATING LYMPHOCYTES; ADOPTIVE IMMUNOTHERAPY; CLINICAL-TRIAL; PHASE-I; ANTITUMOR-ACTIVITY; CD19; ANTIGEN; CD28; MESOTHELIN; LYMPHOMA; CANCER;

D O I：

10.1186/s12943-018-0840-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor treatment is still complicated in the field of medicine. Tumor immunotherapy has been the most interesting research field in cancer therapy. Application of chimeric antigen receptor T (CAR-T) cell therapy has recently achieved excellent clinical outcome in patients, especially those with CD19-positive hematologic malignancies. This phenomenon has induced intense interest to develop CAR-T cell therapy for cancer, especially for solid tumors. However, the performance of CAR-T cell treatment in solid tumor is not as satisfactory as that in hematologic disease. Clinical studies on some neoplasms, such as glioblastoma, ovarian cancer, and cholangiocarcinoma, have achieved desirable outcome. This review describes the history and evolution of CAR-T, generalizes the structure and preparation of CAR-T, and summarizes the latest advances on CAR-T cell therapy in different tumor types. The last section presents the current challenges and prospects of CAR-T application to provide guidance for subsequent research.

引用

页数：10

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