Quantitative Elastography of Liver Fibrosis and Spleen Stiffness in Chronic Hepatitis B Carriers: Comparison of Shear-Wave Elastography and Transient Elastography with Liver Biopsy Correlation

被引：245

作者：

Leung, Vivian Yee-fong ^{[2
]}

Shen, Jiayun ^{[1
,3
]}

Wong, Vincent Wai-sun ^{[1
,3
]}

Abrigo, Jill ^{[2
]}

Wong, Grace Lai-hung ^{[1
,3
]}

Chim, Angel Mei-ling ^{[1
,3
]}

Chu, Shirley Ho-ting ^{[1
,3
]}

Chan, Anthony Wing-hung ^{[4
]}

Choi, Paul Cheung-lung ^{[4
]}

Ahuja, Anil T. ^{[2
]}

Chan, Henry Lik-yuen ^{[1
,3
]}

Chu, Winnie Chiu-wing ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Inst Digest Dis, Shatin 852, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Imaging & Intervent Radiol, Shatin 852, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin 852, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin 852, Hong Kong, Peoples R China

来源：

RADIOLOGY | 2013年 / 269卷 / 03期

关键词：

IMPULSE IMAGING ARFI; NONINVASIVE ASSESSMENT; MR ELASTOGRAPHY; DISEASE; VISCOELASTICITY;

D O I：

10.1148/radiol.13130128

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To document utility of shear-wave (SW) elastography for assessing liver fibrosis in chronic hepatitis B and to compare its performance with that of transient elastography. Materials and Methods: Ethics committee approved the study, and informed consent was obtained. Patients with liver biopsy correlation (n = 226) and healthy patients (n = 171) were analyzed. Results of SW elastography of liver, SW elastography of spleen, and transient elastography of liver were compared and correlated according to METAVIR scores. Areas under the receiver operating characteristic curve (AUCs), binary logistic regression, and Delong test were used. Results: AUC for SW elastography of liver, transient elastography of liver, and SW elastography of spleen was, respectively, 0.86, 0.80, and 0.81 for fibrosis (>= F1 stage); 0.88, 0.78, and 0.82 for moderate fibrosis (>= F2 stage); 0.93, 0.83, and 0.83 for severe fibrosis (>= F3 stage); and 0.98, 0.92, and 0.84 for cirrhosis (F4 stage). SW elastography of liver showed significantly higher accuracy than transient elastography of liver and SW elastography of spleen in all fibrosis stages (P = .01-.04). SW elastography of spleen showed similar accuracy with transient elastography of liver (P = .21-.99). Combination SW elastography of liver and SW elastography of spleen to predict fibrosis staging showed diagnostic accuracy not further improved compared with SW elastography of liver alone (similar AUC; >= F1, P = .87; >= F2, P = .81; >= F3, P = .84; >= F4, P = .88). SW elastography of liver had higher successful rate than transient elastography of liver (98.9% vs 89.6%). Prevalence of discordance in at least two stages with liver histologic staging was 10.2% (23 of 226) for SW elastography of liver and 28.2% (58 of 206) for SW elastography of spleen. Conclusion: SW elastography provides more accurate correlation of liver elasticity with liver fibrosis stage compared with transient elastography, especially in identification of stage F2 or greater. (C) RSNA, 2013

引用

页码：910 / 918

页数：9

共 20 条

[1] Viscoelasticity-based Staging of Hepatic Fibrosis with Multifrequency MR Elastography [J].