Oncogenic MicroRNAs: Key Players in Malignant Transformation

被引：124

作者：

Frixa, Tania ^{[1
]}

Donzelli, Sara ^{[1
]}

Blandino, Giovanni ^{[1
]}

机构：

[1] Regina Elena Inst Canc Res, Translat Oncogen Lab, I-00144 Rome, Italy

来源：

CANCERS | 2015年 / 7卷 / 04期

关键词：

cancer; oncogenic miRNAs; cell cycle regulation; apoptosis; MUTANT P53 GAIN; SQUAMOUS-CELL CARCINOMA; TUMOR-SUPPRESSOR P53; BREAST-CANCER; DRUG-RESISTANCE; COLORECTAL-CANCER; PROSTATE-CANCER; GASTRIC-CANCER; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.3390/cancers7040904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

引用

页码：2466 / 2485

页数：20

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