Pulsatilla saponin D:: the antitumor principle from Pulsatilla koreana

被引：46
|
作者：
Kim, Y [1 ]
Bang, SC [1 ]
Lee, JH [1 ]
Ahn, BZ [1 ]
机构：
[1] SP Pharmaceut Co Ltd, Kong Ju 314923, Chungnam, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 09期
关键词：
Pulsatilla saponin D; antitumor activity;
D O I：
10.1007/BF02975843
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82 %) at the dose of 6.4 mg/kg on the BIDF1 mice bearing LLC cells.
引用
收藏
页码：915 / 918
页数：4
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