Pulsatilla saponin D:: the antitumor principle from Pulsatilla koreana

被引：52

作者：

Kim, Y ^{[1
]}

Bang, SC ^{[1
]}

Lee, JH ^{[1
]}

Ahn, BZ ^{[1
]}

机构：

[1] SP Pharmaceut Co Ltd, Kong Ju 314923, Chungnam, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 09期

关键词：

Pulsatilla saponin D; antitumor activity;

D O I：

10.1007/BF02975843

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82 %) at the dose of 6.4 mg/kg on the BIDF1 mice bearing LLC cells.

引用

页码：915 / 918

页数：4

共 13 条

[1] Bae K, 1999, MED PLANTS KOREA, P139
[2] ANEMONIN, PROTOANEMONIN AND RANUNCULIN FROM KNOWLTONIA-CAPENSIS
CAMPBELL, WE
CRAGG, GML
POWRIE, AH
[J]. PHYTOCHEMISTRY, 1979, 18 (02) : 323 - 324
[3] KANG S S, 1989, Archives of Pharmacal Research (Seoul), V12, P42, DOI 10.1007/BF02855745
[4] Kim SY, 1994, J KOR CANC ASS, V26, P959
[5] Deoxypodophyllotoxin:: The cytotoxic and antiangiogenic component from Pulsatilla koreana
Kim, Y
Kim, SB
You, YJ
Ahn, BZ
[J]. PLANTA MEDICA, 2002, 68 (03) : 271 - 274
[6] KIM Y, 2004, UNPUB PHYTOTHER RES
[7] Li R Z, 1993, Yao Xue Xue Bao, V28, P326
[8] INVITRO ACTIVITY OF PROTOANEMONIN, AN ANTIFUNGAL AGENT
MARTIN, ML
ROMAN, LS
DOMINGUEZ, A
[J]. PLANTA MEDICA, 1990, 56 (01) : 66 - 69
[9] NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING
SKEHAN, P
STORENG, R
SCUDIERO, D
MONKS, A
MCMAHON, J
VISTICA, D
WARREN, JT
BOKESCH, H
KENNEY, S
BOYD, MR
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) : 1107 - 1112
[10] TREUHIRO U, 1996, CANCER RES, V56, P2809

← 1 2 →