Human leucocyte antigen-C in B chronic lymphocytic leukaemia

被引：8
作者：
Montes-Ares, Olga
Moya-Quiles, M. Rosa
Montes-Casado, Maria
Guerra-Perez, Natalia
Campillo, J. Antonio
Gonzalez, Consuelo
Lopez-Bermejo, Antonio
Tamayo, Manuel
Majado, M. Juliana
Parrado, Antonio
Muro, Manuel
Marin, Luis
Alvarez-Lopez, M. Rocio
机构：
[1] Hosp Univ Virgen Arrixaca, Dept Immunol, Murcia, Spain
[2] Hosp Univ Virgen Arrixaca, Dept Haematol, Murcia, Spain
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 135卷 / 04期
关键词：
chronic lymphocytic leukaemia; human leucocyte antigen-C; genetic association; susceptibility; HLA-Cw*16;
D O I：
10.1111/j.1365-2141.2006.06334.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods. The HLA-Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27.6% vs. 12.4%, P = 0.0012, Pc = 0.016). HLA-C dimorphism was also analysed but no association was found.
引用
收藏
页码：517 / 519
页数：3
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