Pharmacogenomics of blood lipid regulation

被引：3

作者：

Legault, Marc-Andre ^{[1
,2
,3
]}

Tardif, Jean-Claude ^{[1
,2
]}

Dube, Marie-Pierre ^{[1
,2
,3
]}

机构：

[1] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada

[2] Univ Montreal, Fac Med, Montreal, PQ H3T 1J4, Canada

[3] Univ Montreal, Beaulieu Saucier Pharmacogen Ctr, Montreal, PQ H1T 1C8, Canada

来源：

PHARMACOGENOMICS | 2018年 / 19卷 / 07期

基金：

加拿大健康研究院;

关键词：

CETP; cholesterol; dalcetrapib; drug development; PCSK9; pharmacogenomics; triglycerides;

D O I：

10.2217/pgs-2018-0007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Blood lipids are important modifiable risk factors for coronary heart disease and various drugs have been developed to target lipid fractions. Considerable efforts have been made to identify genetic variants that modulate responses to drugs in the hope of optimizing their use. Pharmacogenomics and new biotechnologies now allow for meaningful integration of human genetic findings and therapeutic development for increased efficiency and precision of lipid-lowering drugs. Polygenic predictors of disease risk are also changing how patient populations can be stratified, enabling targeted therapeutic interventions to patients more likely to derive the highest benefit, marking a shift from single variant to genomic approaches in pharmacogenomics.

引用

页码：651 / 665

页数：15

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