Regulation mechanism of peptides derived from sea cucumber (Apostichopus japonicas) for modulation of learning and memory

被引：16

作者：

Li, Yanyan ^{[1
]}

Shang, Jing ^{[1
]}

Jiang, Zhenzhou ^{[1
]}

Zhang, Luyong ^{[1
]}

Su, Xiurong ^{[2
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Key Lab Drug Qual Control & Pharmacovigilance, Jiangsu Ctr Pharmacodynam Res & Evaluat,Minist Ed, Nanjing 210009, Jiangsu, Peoples R China

[2] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2016年 / 25卷 / 01期

关键词：

Apostichopus japonicas; peptide; Morris water maze; Gene Microarray; Quantitative Real Time- Polymerase Chain Reaction; STICHOPUS-JAPONICUS; BIOACTIVE PEPTIDES; GENE-EXPRESSION; BODY-WALL; PURIFICATION; MICE; HYDROLYSATE; GELATIN; KINASE; MAZE;

D O I：

10.1007/s10068-016-0035-5

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Peptides derived from the sea cucumber Apostichopus japonicas have immunomodulatory and antioxidant activities. Three dosage levels of peptide hydrolysates were fed to Institute of Cancer Research (ICR) mice. Standardized Y and Morris water mazes were used to determine the effects of A. japonicas peptides on learning and memory. All 3 mouse test groups showed reductions in the latency period (LP), the number of times that a mouse swam over the location of a platform (NCP), the ratio of the distance from a target quadrant to the total swimming distance (DTQ), and the time spent in the target quadrant (TTQ). Microarray analysis was then carried out and 308 genes were differentially expressed between groups, of which 235 were up and 73 were down regulated in the brains of test group animals, compared with control group animals. Expressions of genes identified in microarrays were then analyzed using qRT-PCR.

引用

页码：241 / 246

页数：6

共 31 条

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