A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL

被引：7
作者：
Wang, Peng [1 ,2 ]
Yang, Xi [3 ]
Zhao, Liang [2 ]
Liu, Dongxiao [2 ]
Liu, Junmao [2 ]
Ding, Yongbin [1 ,4 ]
机构：
[1] Nanjing Med Univ, Affiliated Jiangsu Shengze Hosp, Dept Gen Surg, 1399 Shichang Rd, Suzhou, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Hosp Nanjing 2, Dept Gen Surg, 1-1 Zhongfu Rd, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Jiangsu Shengze Hosp, Dept Gastroenterol, 1399 Shichang Rd, Suzhou, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, 300 Guangzhou Rd, Nanjing, Jiangsu, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2019年 / 382卷 / 01期
关键词：
Long non-coding RNA; TONSL-AS1; TONSL; Gastric cancer; GENE; EXPRESSION; TRANSCRIPTION; RECOMBINATION; REPLICATION; SEQUENCE; GENCODE; GROWTH;
D O I：
10.1016/j.yexcr.2019.05.034
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803 cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed that the tumor-inhibiting effect of TONSL-AS1 in gastric cancer cells was associated with TONSL. In general, our results indicated that TONSL-AS1 works as a tumor suppressor lncRNA, which may be a new therapeutic target for gastric cancer.
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页数：10
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