A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL

被引：7

作者：

Wang, Peng ^{[1
,2
]}

Yang, Xi ^{[3
]}

Zhao, Liang ^{[2
]}

Liu, Dongxiao ^{[2
]}

Liu, Junmao ^{[2
]}

Ding, Yongbin ^{[1
,4
]}

机构：

[1] Nanjing Med Univ, Affiliated Jiangsu Shengze Hosp, Dept Gen Surg, 1399 Shichang Rd, Suzhou, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Hosp Nanjing 2, Dept Gen Surg, 1-1 Zhongfu Rd, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Jiangsu Shengze Hosp, Dept Gastroenterol, 1399 Shichang Rd, Suzhou, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, 300 Guangzhou Rd, Nanjing, Jiangsu, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2019年 / 382卷 / 01期

关键词：

Long non-coding RNA; TONSL-AS1; TONSL; Gastric cancer; GENE; EXPRESSION; TRANSCRIPTION; RECOMBINATION; REPLICATION; SEQUENCE; GENCODE; GROWTH;

D O I：

10.1016/j.yexcr.2019.05.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803 cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed that the tumor-inhibiting effect of TONSL-AS1 in gastric cancer cells was associated with TONSL. In general, our results indicated that TONSL-AS1 works as a tumor suppressor lncRNA, which may be a new therapeutic target for gastric cancer.

引用

页数：10

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