Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross

被引：36

作者：

Estelle, J. ^{[1
]}

Perez-Enciso, M.

Mercade, A.

Varona, L.

Alves, E.

Sanchez, A.

Folch, J. M.

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Ciencia Anim & Aliments, Bellaterra 08193, Spain

[2] Inst Catala Recerca & Estudis Avancats, Barcelona 08010, Spain

[3] IRTA, Ctr UdL, Area Prod Anim, Lleida 25198, Spain

[4] INIA, SGIT, Dept Mejora Anim, Madrid 28040, Spain

来源：

ANIMAL GENETICS | 2006年 / 37卷 / 06期

关键词：

fatness; fatty acid binding protein; pig; QTL;

D O I：

10.1111/j.1365-2052.2006.01535.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

We have characterized and mapped the porcine fatty acid binding protein 5, epidermal (FABP5) gene. According to linkage and RH mapping, this gene is located close to the FABP4 (fatty acid binding protein 4, adipocyte) gene on swine chromosome 4. We resequenced 4.7 kb of the FABP5 gene in the parental population of an Iberian x Landrace cross (IBMAP), identifying seven SNPs arranged in two distinct FABP5 haplotypes. QTL and association analyses in the IBMAP population showed that this gene is strongly associated with fat deposition. QTL and haplotype analysis revealed that both FABP4 and FABP5 (clustered in mammals) are major candidate genes for the FAT1 QTL; the most likely position for the FAT1 QTL is between these two genes. Finally, our results suggest the presence of more than one QTL affecting fatness traits on porcine chromosome 4.

引用

页码：589 / 591

页数：3

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