Intracellular Responses Triggered by Cold Atmospheric Plasma and Plasma-Activated Media in Cancer Cells

被引：30
|
作者：
Motaln, Helena [1 ]
Recek, Nina [2 ]
Rogelj, Boris [1 ,3 ,4 ]
机构：
[1] Jozef Stefan Inst, Dept Biotechnol, SI-1000 Ljubljana, Slovenia
[2] Jozef Stefan Inst, Dept Surface Engn, SI-1000 Ljubljana, Slovenia
[3] Biomed Res Inst BRIS, SI-1000 Ljubljana, Slovenia
[4] Univ Ljubljana, Fac Chem & Chem Technol, SI-1000 Ljubljana, Slovenia
来源：
MOLECULES | 2021年 / 26卷 / 05期
关键词：
cold atmospheric plasma (CAP); reactive oxygen species; cell signaling; cell death; OSTEOSARCOMA CELLS; OXIDATIVE STRESS; GENE-EXPRESSION; CARCINOMA-CELLS; APOPTOSIS; MELANOMA; DEATH; PROLIFERATION; INACTIVATION; RETARDATION;
D O I：
10.3390/molecules26051336
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cold atmospheric plasma (CAP), an ionized gas operating at room temperature, has been increasingly studied with respect to its potential use in medicine, where its beneficial effects on tumor reduction in oncology have been demonstrated. This review discusses the cellular changes appearing in cell membranes, cytoplasm, various organelles, and DNA content upon cells' direct or indirect exposure to CAP or CAP-activated media/solutions (PAM), respectively. In addition, the CAP/PAM impact on the main cellular processes of proliferation, migration, protein degradation and various forms of cell death is addressed, especially in light of CAP use in the oncology field of plasma medicine.
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页数：16
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