A single colorimetric sensor for multiple targets: the sequential detection of Co2+ and cyanide and the selective detection of Cu2+ in aqueous solution

A new highly selective and multifunctional chemosensor 1 for the detection of Co2+, Cu2+ and CN-, based on 4-diethylaminosalicyl aldehyde and thiophene-2-carbohydrazide moieties, was designed and synthesized. 1 could simultaneously detect both Co2+ and Cu2+ by changing its color from colorless to yellow in aqueous solution. The binding modes of 1 to Co2+ and Cu2+ were determined to be a 2 : 1 complexation stoichiometry through job plot and ESI-mass spectrometry analysis. The detection limits (0.19 mu M and 0.13 mu M) of 1 for Co2+ and Cu2+ were lower than the DEP guideline (1.7 mu M) of Co2+ and the WHO guideline (31.5 mu M) of Cu2+ for drinking water. Importantly, 1 could detect and quantify Co2+ and Cu2+ in real water samples. Moreover, the resulting Co2+-2$ 1 complex sensed cyanide through naked-eye, showing recovery from Co2+-2.1 to 1. The sensing mechanisms of Cu2+ by 1 were explained by theoretical calculations.