In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney

被引：12
|
作者：
Ncir, Marwa [1 ]
Saoudi, Mongi [1 ]
Sellami, Hanen [2 ,3 ]
Rahmouni, Fatma [4 ]
Lahyani, Amina [5 ]
Ayadi, Fatma Makni [5 ]
El Feki, Abdelfattah [1 ]
Allagui, Mohamed Salah [1 ]
机构：
[1] Univ Sfax, Sci Fac Sfax, Anim Ecophysiol Lab, Sfax, Tunisia
[2] Univ Sfax, Fac Sci Sfax, Lab Rech Toxicol Microbiol Environm & Sante LR17E, Sfax, Tunisia
[3] Univ Carthage, Water Res & Technol Ctr CERTE, LTVRH, Nabeul, Tunisia
[4] Univ Sfax, Fac Med, Lab Histol & Embryol, Sfax, Tunisia
[5] CHU HabibBourguiba Sfax, Biochem Lab, Sfax, Tunisia
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 124卷 / 03期
关键词：
Deltamethrin; Allium sativum extracts; antioxidant activities; oxidative stress; AGED GARLIC EXTRACT; ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; FLAVONOIDS CONTENT; PHENOLIC CONTENT; VARIETIES; L; ACETYLCHOLINESTERASE; DAMAGE; EXPOSURE;
D O I：
10.1080/13813455.2017.1376335
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study investigated the in vitro and the in vivo antioxidant capacities of Allium sativum (garlic) extract against deltamethrin-induced oxidative damage in rat's brain and kidney. The in vitro result showed that highest extraction yield was achieved with methanol (20.08%). Among the tested extracts, the methanol extract exhibited the highest total phenolic, flavonoids contents and antioxidant activity. The in vivo results showed that deltamethrin treatment caused an increase of the acetylcholinesterase level (AChE) in brain and plasma, the brain and kidney conjugated dienes and lipid peroxidation (LPO) levels as compared to control group. The antioxidant enzymes results showed that deltamethrin treatment induced a significantly decrease (p < 0.01) in brain and kidney antioxidant enzymes as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) to control group. The co-administration of garlic extract reduced the toxic effects in brain and kidney tissues induced by deltamethrin.
引用
收藏
页码：207 / 217
页数：11
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