Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells

被引：37
|
作者：
Yang, Xuelin [1 ]
Wang, Wei [1 ]
Tan, Jun [1 ]
Song, Dandan [1 ]
Li, Ming [1 ]
Liu, Dan [1 ]
Jing, Yongkui [2 ]
Zhao, Linxiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
[2] Mt Sinai Sch Med, New York, NY 10029 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Apoptosis; Artemisinin; Leukemia; Structure-activity relationships; Synthesis; ARTEMISININ DERIVATIVES;
D O I：
10.1016/j.bmcl.2009.05.076
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fifteen dihydroartemisinin derivatives containing a substituted chalcone linked by either ether or ester were synthesized and investigated for their cytotoxicity in human leukemia HL-60 and mouse lymphoma P388 cells. These derivatives have greater antiproliferative and cytotoxic effects in both cell lines than dihydroartemisinin. Dihydroartemisinin chalcones linked by ether are more cytotoxic than dihydroartemisinin chalcones linked by ester with apoptosis induction abilities. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4385 / 4388
页数：4
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