HSC Aging and Senescent Immune Remodeling

被引：88
作者：
Denkinger, Michael D. [1 ,2 ,3 ,4 ]
Leins, Hanna [3 ,5 ]
Schirmbeck, Reinhold [5 ]
Florian, Maria Carolina [1 ,2 ]
Geiger, Hartmut [1 ,2 ,6 ,7 ]
机构：
[1] Univ Ulm, Inst Mol Med Stem Cells & Aging, D-89069 Ulm, Germany
[2] Univ Ulm, Aging Res Ctr, D-89069 Ulm, Germany
[3] Univ Ulm, AGAPLES Bethesda Clin, Geriatr Med, D-89069 Ulm, Germany
[4] Geriatr Ctr Ulm Alb Donau, Ulm, Germany
[5] Univ Hosp Ulm, Dept Internal Med 1, Ulm, Germany
[6] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA
[7] Univ Cincinnati, Cincinnati, OH USA
来源：
TRENDS IN IMMUNOLOGY | 2015年 / 36卷 / 12期
基金：
美国国家卫生研究院;
关键词：
T-CELLS ACCUMULATE; MODERATE EXERCISE; NATURAL-KILLER; AGE; IMMUNOSENESCENCE; NAIVE; INFLAMMATION; REGENERATION; DECLINE; WNT;
D O I：
10.1016/j.it.2015.10.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aging-associated changes in the function of the immune system are referred to as senescent immune remodeling (SIR). Here we review the current understanding on the cellular and molecular mechanisms underlying SIR. We focus on aging-associated changes in T and B cells, and discuss recent evidence supporting the notion that aging of the hematopoietic stem cell (HSC) compartment directly contributes to SIR due to aging-associated alterations in stem cell differentiation. We conclude by outlining strategies to attenuate SIR, including approaches to rejuvenate HSCs, which may open new avenues for targeting SIR in the clinic.
引用
收藏
页码：815 / 824
页数：10
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