Signal-to-noise and radiation exposure considerations in conventional and diffraction x-ray microscopy

被引：57

作者：

Huang, Xiaojing ^{[1
]}

Miao, Huijie ^{[1
]}

Steinbrener, Jan ^{[1
]}

Nelson, Johanna ^{[1
]}

Shapiro, David ^{[2
]}

Stewart, Andrew ^{[1
]}

Turner, Joshua ^{[1
]}

Jacobsen, Chris ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Phys & Astron, Stony Brook, NY 11794 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Adv Light Source, Berkeley, CA 94720 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 16期

关键词：

COMPUTED-TOMOGRAPHY; TRANSMISSION; RESOLUTION; RECONSTRUCTION; YEAST; RATIO;

D O I：

10.1364/OE.17.013541

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Using a signal-to-noise ratio estimation based on correlations between multiple simulated images, we compare the dose efficiency of two soft x-ray imaging systems: incoherent brightfield imaging using zone plate optics in a transmission x-ray microscope (TXM), and x-ray diffraction microscopy (XDM) where an image is reconstructed from the far-field coherent diffraction pattern. In XDM one must computationally phase weak diffraction signals; in TXM one suffers signal losses due to the finite numerical aperture and efficiency of the optics. In simulations with objects representing isolated cells such as yeast, we find that XDM has the potential for delivering equivalent resolution images using fewer photons. This can be an important advantage for studying radiation-sensitive biological and soft matter specimens. (C) 2009 Optical Society of America

引用

页码：13541 / 13553

页数：13

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