Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells

被引:100
作者
Benten, WPM
Lieberherr, M
Sekeris, CE
Wunderlich, F
机构
[1] UNIV DUSSELDORF, DIV MOL PARASITOL, D-40225 DUSSELDORF, GERMANY
[2] UNIV DUSSELDORF, CTR BIOL & MED RES, D-40225 DUSSELDORF, GERMANY
[3] INRA, CNRS, URA 583, F-78352 JOUY EN JOSAS, FRANCE
[4] NATL HELLEN RES FDN, INST BIOL RES & BIOTECHNOL, GR-11635 ATHENS, GREECE
关键词
testosterone; Ca2+ influx; T cell; androgen receptor; membrane receptor;
D O I
10.1016/S0014-5793(97)00346-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using the Fura-2 method we investigated a possible direct action of testosterone on cytosolic free calcium of splenic T cells isolated from female C57BL/10 mice, Testosterone at physiological concentrations of 1-10 nM induces an increase in [Ca2+](i) within seconds, which is due to Ca2+ influx and not to Ca2+ release from intracellular stores, In contrast, estradiol induces both Ca2+ influx and Ca2+ release, The testosterone-induced Ca2+ influx is mediated by Ni2+-blockable channels and is not inhibited by cyproterone, a blocker of the classical androgen receptor, Ca2+ influx can also be induced by testosterone conjugated to BSA which is impermeable to the plasma membrane, These data indicate a novel mode of direct action of testosterone on T cells which is not mediated through the classical androgen receptor response, but through unconventional plasma membrane receptors. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:211 / 214
页数:4
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