Synthesis and Antimicrobial Characterization of Luotonin Derivatives

被引：2
|
作者：
Zhu, Rui [1 ]
Guo, Rui [2 ]
Han, Ke [1 ]
Xi, Wenying [1 ]
Zheng, Shaojun [1 ,2 ]
Zhang, Jiwen [2 ]
机构：
[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang, Jiangsu, Peoples R China
[2] Northwest A&F Univ, Key Lab Bot Pesticide R&D Shaanxi Prov, Yangling, Shaanxi, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 12期
基金：
中国国家自然科学基金;
关键词：
luotonin derivatives; synthesis; antimicrobial; agrochemicals; bioactivity; ALKALOIDS;
D O I：
10.1177/1934578X20952750
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Twenty-one novel luotonin derivatives were synthesized from 2-aminobenzamide in excellent yields. The prepared compounds, when tested against 8 strains of bacteria and many plant pathogen fungi showed diverse and promising antimicrobial activities. Notably, compounds a5, a9, b4, and b5 demonstrated good activities and might be potential lead compounds for further development as antifungal agents. The relationship between structure and biological activity is also discussed.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Synthesis and Characterization of Benzimidazole Derivatives and Evaluation of Antimicrobial activity
    Vyas, Kamal Kant
    Rajpurohit, Sangeeta
    Vaishnav, Yudhishthir
    ORIENTAL JOURNAL OF CHEMISTRY, 2023, 39 (04) : 996 - 1001
  • [22] Synthesis, Characterization and Antimicrobial Activities of Mercaptoxadiazoles, Mercaptotriazoles and their Derivatives
    Mumtaz, Amara
    Saeed, Aamer
    Malik, Imran
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2014, 36 (05): : 852 - 857
  • [23] Synthesis, characterization, and antimicrobial activity of new benzofuran derivatives
    R. Kenchappa
    Yadav D. Bodke
    Sandeep Telkar
    M. Aruna Sindhe
    M. Giridhar
    Russian Journal of General Chemistry, 2016, 86 : 2827 - 2836
  • [24] An efficient synthesis, characterization, and antimicrobial screening of tetrahydropyrimidine derivatives
    Godhani, Dinesh R.
    Dobariya, Purvesh B.
    Jogel, Anand A.
    Sanghani, Anil M.
    Mehta, Jignasu P.
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (05) : 2417 - 2425
  • [25] Synthesis, Characterization and Antimicrobial Activity of Azetidinone and Thiazolidinone Derivatives
    Sankar, P. Siva
    Divya, K.
    Reddy, G. Dinneswara
    Padmavathi, V
    Zyryanov, Grigory, V
    PROCEEDINGS OF THE II INTERNATIONAL CONFERENCE: MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2018), 2019, 2063
  • [26] Total synthesis of luotonin A
    Kelly, TR
    Chamberland, S
    Silva, RA
    TETRAHEDRON LETTERS, 1999, 40 (14) : 2723 - 2724
  • [27] Synthesis, Characterization and Antimicrobial Activity of New Pyrrole Derivatives
    Idhayadhulla, Akbar
    Kumar, Radhakrishnan Surendra
    Nasser, Abdul Jamal Abdul
    JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2011, 55 (04) : 218 - 223
  • [28] Synthesis, Characterization and Antimicrobial Activity of New Thiadiazole Derivatives
    Mullick, Pooja
    Khan, Suroor A.
    Verma, Surajpal
    Alam, Ozair
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2010, 31 (08) : 2345 - 2350
  • [29] Synthesis, characterization, and antimicrobial activity of new benzofuran derivatives
    Kenchappa, R.
    Bodke, Yadav D.
    Telkar, Sandeep
    Sindhe, M. Aruna
    Giridhar, M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (12) : 2827 - 2836
  • [30] Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi
    Wang, Ren-Xuan
    Du, Sha-Sha
    Wang, Jing-Ru
    Chu, Qing-Ru
    Tang, Chen
    Zhang, Zhi-Jun
    Yang, Cheng-Jie
    He, Ying-Hui
    Li, Hai-Xing
    Wu, Tian-Lin
    Liu, Ying-Qian
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 69 (48) : 14467 - 14477
12345