Synthesis and Antimicrobial Characterization of Luotonin Derivatives

被引：2
作者：
Zhu, Rui [1 ]
Guo, Rui [2 ]
Han, Ke [1 ]
Xi, Wenying [1 ]
Zheng, Shaojun [1 ,2 ]
Zhang, Jiwen [2 ]
机构：
[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang, Jiangsu, Peoples R China
[2] Northwest A&F Univ, Key Lab Bot Pesticide R&D Shaanxi Prov, Yangling, Shaanxi, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 12期
基金：
中国国家自然科学基金;
关键词：
luotonin derivatives; synthesis; antimicrobial; agrochemicals; bioactivity; ALKALOIDS;
D O I：
10.1177/1934578X20952750
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Twenty-one novel luotonin derivatives were synthesized from 2-aminobenzamide in excellent yields. The prepared compounds, when tested against 8 strains of bacteria and many plant pathogen fungi showed diverse and promising antimicrobial activities. Notably, compounds a5, a9, b4, and b5 demonstrated good activities and might be potential lead compounds for further development as antifungal agents. The relationship between structure and biological activity is also discussed.
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页数：6
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