Aims: To present 18 cases of spindle cell thymoma (WHO type A) with prominent neuroendocrine morphology. Methods and results: The patients were nine men and nine women aged 36-76 years (average: 56 years). Clinically, the patients presented with non-specific symptoms such as chest pain, or were entirely asymptomatic. None of the patients had a history of autoimmune syndrome. Surgical resection was performed in all patients. The tumour size ranged from 30 to 110 mm. Macroscopically, the tumours were described as light brown or tan masses with a homogeneous and solid appearance. Microscopically, all tumours showed areas that closely resembled the typical growth pattern of neuroendocrine tumours, i.e. rosette-like structures or a trabecular, insular or ribbon-like arrangement of tumour cells. Areas of more conventional spindle cell thymoma were present in all cases. Seven cases were encapsulated, and 10 cases were invasive tumours. Immunohistochemically, the tumours were positive for pancytokeratin but negative for synaptophysin and chromogranin A. Follow-up information for 10 patients showed that all patients were alive after a period ranging from 1 month to 6 years. Conclusions: Familiarity with this particular pattern of thymoma is important in order to separate this tumour from true neuroendocrine carcinoma and prevent unnecessary adjuvant treatment.
机构:
Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R ChinaSichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Zhu, Hong
Li, Ke
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Li, Ke
Dong, Dan-dan
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Dong, Dan-dan
Fu, Jing
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Fu, Jing
Liu, Dan-dan
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Liu, Dan-dan
Wang, Lei
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Wang, Lei
Xu, Gang
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
Xu, Gang
Song, Lin-hong
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机构:Sichuan Acad Med Sci, Dept Pathol, Chengdu 610072, Peoples R China
机构:
Japan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Japan Self Def Forces Cent Hosp, Hlth Care Ctr, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Matsukuma, Susumu
Obara, Kiyohaya
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Japan Self Def Forces Cent Hosp, Div Thorac Surg, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Obara, Kiyohaya
Kato, Kimi
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Japan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Kato, Kimi
Ohshika, Yoshiro
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Japan Self Def Forces Cent Hosp, Div Thorac Surg, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Ohshika, Yoshiro
Takeo, Hiroaki
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Japan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Takeo, Hiroaki
Tsuchiya, Satoshi
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Japan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan
Tsuchiya, Satoshi
Sato, Kimiya
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Japan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, JapanJapan Self Def Forces Cent Hosp, Dept Pathol, Setagaya Ku, Tokyo 1548532, Japan