Combination of Asciminib plus Nilotinib or Asciminib plus Dasatinib in Previously Treated Chronic Myeloid Leukemia (CML) Patients: Phase 1 Study Results

被引：4

作者：

DeAngelo, Daniel J. ^{[1
]}

Mauro, Michael J. ^{[2
]}

Kim, Dong-Wook ^{[3
]}

Cortes, Jorge ^{[4
]}

Rea, Delphine ^{[5
]}

Hughes, Timothy P. ^{[6
,7
]}

Minami, Hironobu ^{[8
]}

Breccia, Massimo ^{[9
]}

Talpaz, Moshe ^{[10
]}

Hochhaus, Andreas ^{[11
]}

Goh, Yeow Tee ^{[12
]}

Le Coutre, Philipp D. ^{[13
]}

Sondhi, Manu ^{[14
]}

Mishra, Kaushal ^{[14
]}

Hourcade-Potelleret, Florence ^{[15
]}

Vanasse, Gary ^{[15
]}

Aimone, Paola ^{[15
]}

Lang, Fabian ^{[16
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[3] Catholic Univ Korea, Seoul St Marys Hosp, Leukemia Res Inst, Seoul, South Korea

[4] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[5] Hop St Louis, Paris, France

[6] SA Pathol, Adelaide, SA, Australia

[7] Univ Adelaide, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[8] Kobe Univ Hosp, Kobe, Hyogo, Japan

[9] Univ Roma La Sapienza, Rome, Italy

[10] Univ Michigan, Ann Arbor, MI 48109 USA

[11] Univ Klinikum Jena, Abt Hamatol Onkol, Jena, Germany

[12] Singapore Gen Hosp, Singapore, Singapore

[13] Charite Univ Med Berlin, Berlin, Germany

[14] Novartis Pharmaceut, E Hanover, NJ USA

[15] Novartis Pharma AG, Basel, Switzerland

[16] Goethe Univ Frankfurt Main, Frankfurt, Germany

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2019年 / 19卷

关键词：

asciminib; tyrosine kinase inhibitor; clinical trial; CML; chronic myelogenous leukemia;

D O I：

10.1016/j.clml.2019.07.236

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CML-102

引用

页码：S290 / S291

页数：3

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[31] Tolerability of Asciminib vs Investigator-Selected (IS) Tyrosine Kinase Inhibitors (TKIs) in the Phase 3 ASC4FIRST Study in Newly Diagnosed Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) [J].

Issa, Ghayas C. ;

Larson, Richard A. ;

Hughes, Timothy P. ;

Hochhaus, Andreas ;

Takahashi, Naoto ;

Bombaci, Felice ;

Wang, Jianxiang ;

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Dong, Dennis ;

Kim, Hwan ;

Gu, Ennan ;

Zhang, Yifan ;

Kapoor, Shruti ;

Agrawal, Nithya ;

Jinwal, Rajendra ;

Damon, Andrea ;

Sadek, Islam ;

Cortes, Jorge E. .

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[32] Efficacy and Safety Results From ASCEMBL, a Phase III Study of Asciminib vs. Bosutinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) After.2 Prior Tyrosine Kinase Inhibitors (TKIs): Week 96 Update [J].

Rea, Delphine ;

Hochhaus, Andreas ;

Mauro, Michael J. ;

Minami, Yosuke ;

Lomaia, Elza ;

Voloshin, Sergey ;

Turkina, Anna ;

Kim, Wook ;

Apperley, Jane F. ;

Cortes, Jorge E. ;

Abdo, Andre ;

Fogliatto, Laura Marie ;

Kim, Dennis Dong Hwan ;

le Coutre, Philipp ;

Saussele, Susanne ;

Annunziata, Mario ;

Hughes, Timothy P. ;

Chaudhri, Naeem ;

Chee, Lynette ;

Garcia-Gutierrez, Valentin ;

Sasaki, Koji ;

Kapoor, Shruti ;

Allepuz, Alex ;

Quenet, Sara ;

Bedoucha, Veronique ;

Boquimpani, Carla .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 :S295-S296

[33] A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph plus CML or relapsed/refractory Ph plus ALL [J].

Tojo, Arinobu ;

Usuki, Kensuke ;

Urabe, Akio ;

Maeda, Yasuhiro ;

Kobayashi, Yukio ;

Jinnai, Itsuro ;

Ohyashiki, Kazuma ;

Nishimura, Miki ;

Kawaguchi, Tatsuya ;

Tanaka, Hideo ;

Miyamura, Koichi ;

Miyazaki, Yasushi ;

Hughes, Timothy ;

Branford, Susan ;

Okamoto, Shinichiro ;

Ishikawa, Jun ;

Okada, Masaya ;

Usui, Noriko ;

Tanii, Hiromi ;

Amagasaki, Taro ;

Natori, Hiroko ;

Naoe, Tomoki .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2009, 89 (05) :679-688

[34] A Propensity Score Matching Analysis of Dasatinib and Nilotinib as a Frontline Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase [J].

Takahashi, Koichi ;

Kantarjian, Hagop M. ;

Yang, Yulong ;

Sasaki, Koji ;

Jain, Preetesh ;

DellaSala, Sara ;

Ravandi, Farhad ;

Kadia, Tapan ;

Pemmaraju, Naveen ;

Daver, Naval ;

Borthakur, Gautam ;

Garcia-Manero, Guillermo ;

Jabbour, Elias ;

Cortes, Jorge E. .

CANCER, 2016, 122 (21) :3336-3343

[35] ENESTop 192-Weeks Results: Treatment-Free Remission (TFR) in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) After Stopping Second-Line Nilotinib [J].

Mahon, Francois-Xavier ;

Boquimpani, Carla ;

Takahashi, Naoto ;

Benyamini, Noam ;

Clementino, Nelma Cristina D. ;

Shuvaev, Vasily ;

Lipton, Jeffrey H. ;

Turkina, Anna G. ;

De Paz Arias, Raquel ;

Moiraghi, Beatriz ;

Nicolini, Franck E. ;

Dengler, Jolanta ;

Sacha, Tomasz ;

Kim, Dong-Wook ;

Fellague-Chebra, Rafik ;

Tiwari, Ranjan ;

Bouard, Catherine ;

Hughes, Timothy P. .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 :S288-S289

[36] Asciminib Provides Durable Molecular Responses in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With the T315I Mutation: Updated Efficacy and Safety Data From a Phase I Trial [J].

Hughes, Timothy P. ;

Cortes, Jorge E. ;

Rea, Delphine ;

Mauro, Michael J. ;

Hochhaus, Andreas ;

Kim, Dong-Wook ;

Sasaki, Koji ;

Lang, Fabian ;

Heinrich, Michael C. ;

Breccia, Massimo ;

Deininger, Michael ;

Goh, Yeow-Tee ;

Janssen, Jeroen J. W. M. ;

Talpaz, Moshe ;

le Coutre, Philipp ;

Kapoor, Shruti ;

Cacciatore, Silvia ;

Polydoros, Fotis ;

Agrawal, Nithya ;

Mahon, Francois-Xavier .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 :S300-S300

[37] Results of Dasatinib Therapy in Patients With Early Chronic-Phase Chronic Myeloid Leukemia [J].

Cortes, Jorge E. ;

Jones, Dan ;

O'Brien, Susan ;

Jabbour, Elias ;

Ravandi, Farhad ;

Koller, Charles ;

Borthakur, Gautam ;

Walker, Brenda ;

Zhao, Weiqiang ;

Shan, Jianqin ;

Kantarjian, Hagop .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :398-404

[38] Treatment-Free Remission (TFR) Following Frontline Nilotinib in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): 192-Weeks Data from the ENESTfreedom Study [J].

Radich, Jerald P. ;

Ross, David M. ;

Masszi, Tamas ;

Gomez Casares, Maria Teresa ;

Hellmann, Andrzej ;

Stentoft, Jesper ;

Conneally, Eibhlin ;

Garcia Gutierrez, Valentin ;

Gattermann, Norbert ;

Le Coutre, Philipp D. ;

Martino, Bruno ;

Saussele, Susanne ;

Giles, Francis J. ;

Saglio, Giuseppe ;

Sondhi, Manu ;

Mishra, Kaushal ;

Aimone, Paola ;

Hochhaus, Andreas .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 :S288-S288

[39] Asciminib in Patients With CML-CP Previously Treated With ≥ 2 Tyrosine Kinase Inhibitors: 96-Week Results From the Japanese Subgroup Analysis of the ASCEMBL Study [J].

Minami, Yosuke ;

Doki, Noriko ;

Matsuoka, Hiroshi ;

Yokota, Takafumi ;

Tomita, Akihiro ;

Takahashi, Naoto ;

Kubo, Kohmei ;

Goto, Tatsunori ;

Kirito, Keita ;

Maki, Akio ;

Aoki, Makoto ;

Dawson, Meryem Ktiouet ;

Matsumura, Itaru .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2024, 120 (03) :305-313

[40] Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph plus chronic myeloid leukemia in chronic phase [J].

Larson, Richard A. ;

Yin, Ophelia Q. P. ;

Hochhaus, Andreas ;

Saglio, Giuseppe ;

Clark, Richard E. ;

Nakamae, Hirohisa ;

Gallagher, Neil J. ;

Demirhan, Eren ;

Hughes, Timothy P. ;

Kantarjian, Hagop M. ;

le Coutre, Philipp D. .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 68 (05) :723-733

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