Revaluation of chloroquine therapeutic efficacy on children with uncomplicated Plasmodium falciparum malaria in eastern Ivory Coast (1999-2002)

被引：1

作者：

Adoubryn, KD ^{[1
]}

Ouhon, J ^{[1
]}

Yapo, CG ^{[1
]}

N'guettia, KS ^{[1
]}

Kouakou, KAE ^{[1
]}

Adou, SJ ^{[1
]}

Kouabenan, A ^{[1
]}

Assoumou, A ^{[1
]}

机构：

[1] UFR Sci Med, Lab Parasitol Mycol, Abidjan, Cote Ivoire

来源：

MEDECINE ET MALADIES INFECTIEUSES | 2004年 / 34卷 / 03期

关键词：

chloroquine; malaria; Plasmodium falciparum;

D O I：

10.1016/j.medmal.2003.11.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective. - A prospective study was made from November 1999 to May 2002 in order to revaluate the therapeutic efficacy of chloroquine in pediatric Plamodium falciparum malaria in Ivory Coast. Design. - This study was included in the national Plasmodium falciparum-susceptibility supervision program. Two hundred and fifty-six out of 594 patients from six to 59 months of age were included. Chloroquine was administered in accordance with the standard 14 day WHO protocol; i.e. administered dose of 25 mg/kg, in split doses, over three days. Results. - Two hundred and forty-seven patients completed the treatment. Among these, 217 presented with adequate clinical response (87.8%). The percentage of therapeutic failure was 12.2% with 12 early cases of therapeutic failure and 18 late cases of therapeutic failure. Chloroquine was more efficacious in Agnibilekrou (11.3% of therapeutic failure), Bondoukou (10.4%), and Tanda (10%), than in Abengourou (16.4%). Parasitic reduction on patients with resistant Plasmodium was superior to 90%, from day 0 to day 3. The risk of therapeutic failure was significantly linked to patient age. Conclusion. - Considering these results, the authors suggest that the first-line treatment with chloroquine must be continued for uncomplicated malaria in humans. (C) 2003 Elsevier SAS. Tons droits reserves.

引用

页码：127 / 131

页数：5

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