Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water

被引：15
作者：
He, Ping [1 ]
Haswell, Stephen J. [1 ]
Pamme, Nicole [1 ]
Archibald, Stephen J. [1 ,2 ]
机构：
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England
[2] Univ Hull, Positron Emiss Tomog Res Ctr, Kingston Upon Hull HU6 7RX, N Humberside, England
来源：
APPLIED RADIATION AND ISOTOPES | 2014年 / 91卷
关键词：
Electrochemical cell; Fluorine-18; Separation; Positron emission tomography; FDG; Radiochemical synthesis; POSITRON-EMISSION-TOMOGRAPHY; ANION-EXCHANGE RESIN; F-18; FLUORIDE; NO-CARRIER; ELECTROCHEMICAL-CELL; O-18; WATER; ROUTINE PRODUCTION; IN-VIVO; RECOVERY; RADIOFLUORINATION;
D O I：
10.1016/j.apradiso.2014.04.021
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [F-18]fluorodeoxyglucose ([F-18]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [F-18]fluoride from [O-18]water. There are many methods reported in literature for the isolation of [F-18]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [F-18]fluoride ions from [O-18]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of F-18 PET tracers. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：64 / 70
页数：7
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