Macrophage diversity and polarization: in vivo veritas

被引:75
作者
Mantovani, Alberto [1 ]
机构
[1] Ist Clin Humanitas, Rozzano, Italy
关键词
D O I
10.1182/blood-2006-05-019430
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polarized activation of cells of the monocyte-macrophage lineage into M1 and M2 cells is an operationally useful, simplified descriptor of the functional plasticity of these cells. Ghassabeh and colleagues now put to the test the actual in vivo validity and significance of the M1/M2 paradigm.
引用
收藏
页码:408 / 409
页数:2
相关论文
共 5 条
  • [1] A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)
    Biswas, SK
    Gangi, L
    Paul, S
    Schioppa, T
    Saccani, A
    Sironi, M
    Bottazzi, B
    Doni, A
    Vincenzo, B
    Pasqualini, F
    Vago, L
    Nebuloni, M
    Mantovani, A
    Sica, A
    [J]. BLOOD, 2006, 107 (05) : 2112 - 2122
  • [2] Blocking IL-1 in systemic inflammation
    Dinarello, CA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (09) : 1355 - 1359
  • [3] Alternative activation of macrophages
    Gordon, S
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) : 23 - 35
  • [4] Macrophage polarization comes of age
    Mantovani, A
    Sica, A
    Locati, M
    [J]. IMMUNITY, 2005, 23 (04) : 344 - 346
  • [5] The chemokine system in diverse forms of macrophage activation and polarization
    Mantovani, A
    Sica, A
    Sozzani, S
    Allavena, P
    Vecchi, A
    Locati, M
    [J]. TRENDS IN IMMUNOLOGY, 2004, 25 (12) : 677 - 686