Synthesis of (Pyridin-2-YL)Hydrazone Rhenium(I) Tricarbonyl Complexes that Exhibit pH-Sensitive Fluorescence

被引：6

作者：

Hapuarachchige, S. ^{[1
]}

Bryant, B. K. ^{[1
]}

Arterburn, J. B. ^{[1
]}

机构：

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 02期

关键词：

chelate; estrogen; hydrazone; tricarbonylrhenium; fluorescence; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CRYSTAL-STRUCTURE; LIGANDS; REACTIVITY; BEHAVIOR; FUNCTIONALIZATION; COORDINATION; GLUCOSE; SYSTEMS;

D O I：

10.1007/s10593-014-1469-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

There is great potential for novel diagnostic and therapeutic agents that combine multiple imaging modalities. The combination of optical and radionuclide imaging systems is particularly promising for the improved management of cancer. We describe a new heteroorganometallacyclic system containing the (2-pyridyl)hydrazono-Re(CO)(3) that exhibits pH-sensitive photophysical properties. This optical reporter group was easily incorporated into a novel synthetic probe for targeting estrogen receptors in cancer. The efficient complexation conditions are expected to be compatible with Tc-99m-radiolabeling to obtain dual function imaging probes.

引用

页码：254 / 263

页数：10

共 35 条

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