Photoredox Defluorinative Alkylation of 1-Trifluoromethyl Alkenes and 1,3-Butadienes with 1,4-Dihydropyridines as Alkylation Reagents

被引：53

作者：

Chen, Haoguo ^{[1
]}

Anand, Devireddy ^{[1
]}

Zhou, Lei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 05期

基金：

中国国家自然科学基金;

关键词：

alkylation; C-F bond cleavage; difluoroalkenes; photoredox; radicals; NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION; GEM-DIFLUOROALKENES; ADDITION-REACTION; RADICAL-ADDITION; ALPHA; FLUORINE; 4-ALKYL-1,4-DIHYDROPYRIDINES; FUNCTIONALIZATION; ELIMINATION; ESTERS;

D O I：

10.1002/ajoc.201900026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A radical defluorinative alkylation method of 1-trifluoromethyl alkenes and 1,3-butadienes with 4-alkyl-1,4-dihydropyridines under visible light irradiation is presented. Various alkylated 1,1-difluoroalkenes and 1,1-difluorodienes were obtained in moderate to high yields through a sequential C-C and C-F bond cleavage process.

引用

页码：661 / 664

页数：4

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