Design and synthesis of triazole-containing macrocylclic tetrapeptide as novel Grb2 SH2 domain ligands

被引:0
|
作者
Shi, Zhen-Dan
Worthy, Karen M.
Fisher, Robert J.
Burke, Terrence R., Jr.
机构
[1] NCI, Med Chem Lab, CCR, NIH, Frederick, MD 21702 USA
[2] SAIC Frederick, Prot Chem Lab, Frederick, MD USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
242-MEDI
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization
    Clements, John H.
    DeLorbe, John E.
    Benfield, Aaron P.
    Martin, Stephen F.
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2010, 66 : 1101 - 1115
  • [22] Monocarboxylic-based phosphotyrosyl mimetics in the design of Grb2 SH2 domain inhibitors
    Burke, TR
    Luo, J
    Yao, ZJ
    Gao, Y
    Zhao, H
    Milne, GWA
    Guo, RB
    Voigt, JH
    King, CR
    Yang, DJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (03) : 347 - 352
  • [23] Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance
    Lung, FDT
    Tsai, JY
    Wei, SY
    Cheng, JW
    Chen, C
    Li, P
    Roller, PP
    JOURNAL OF PEPTIDE RESEARCH, 2002, 60 (03): : 143 - 149
  • [24] Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display
    Gram, H
    Schmitz, R
    Zuber, JF
    Baumann, G
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 246 (03): : 633 - 637
  • [25] Synthesis of Grb2 SH2 Domain Proteins for Mirror-Image Screening Systems
    Noguchi, Taro
    Ishiba, Hiroyuki
    Honda, Kaori
    Kondoh, Yasumitsu
    Osada, Hiroyuki
    Ohno, Hiroaki
    Fujii, Nobutaka
    Oishi, Shinya
    BIOCONJUGATE CHEMISTRY, 2017, 28 (02) : 609 - 619
  • [26] INDEPENDENT BINDING OF PEPTIDE LIGANDS TO THE SH2 AND SH3 DOMAINS OF GRB2
    LEMMON, MA
    LADBURY, JE
    MANDIYAN, V
    ZHOU, M
    SCHLESSINGER, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (50) : 31653 - 31658
  • [27] Grb2 SH2 domain targeted inhibitors functioning in cellular signaling
    Lung, FDT
    Rosenberg, K
    Sastry, L
    Wang, S
    Wu, XW
    King, CR
    Roller, PP
    PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, : 218 - 220
  • [28] Application of phenylphosphate mimetics to the design and synthesis of olefin metathesisderived Grb2 SH2 domain-binding macrocycles
    Burke, TR
    Kang, SU
    Choi, WJ
    Shi, ZD
    Karki, R
    Phan, J
    Worthy, KM
    Bindu, LK
    Nicklaus, M
    Waugh, DS
    Fisher, RJ
    BIOPOLYMERS, 2005, 80 (04) : 536 - 536
  • [29] Design and synthesis of a novel phosphatase-stable beta-amino acid pTyr mimetic and its utilization in the preparation of novel Grb2 SH2 domain ligands.
    Lee, K
    Zhang, MC
    Yang, DJ
    Burke, TR
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U24 - U24
  • [30] Novel phosphotyrosyl mimetics for the preparation of potent small molecule Grb2 SH2 domain inhibitors
    Gao, Y
    Yao, ZJ
    Voigt, D
    Luo, JH
    Yang, DJ
    Burke, TR
    PEPTIDES FOR THE NEW MILLENNIUM, 2000, : 566 - 567