Convenient palladium-catalyzed preparation of primary anilines using a fluorous benzophenone imine reagent

被引：33

作者：

Cioffi, CL ^{[1
]}

Berlin, ML ^{[1
]}

Herr, RJ ^{[1
]}

机构：

[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12212 USA

来源：

SYNLETT | 2004年 / 05期

关键词：

amination; arylation; cross-coupling; palladium-catalyzed; fluorous;

D O I：

10.1055/s-2004-820011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel fluoroalkyl benzophenone imine reagent (f-BPI) serves as a convenient ammonia surrogate for the palladium-catalyzed Buchwald-Hartwig amination of aryl halides. The highly fluorinated imine moiety acts as a handle for rapid purification of intermediates using fluorous chromatographic techniques, and is removed in a subsequent stage by acid hydrolysis to provide the corresponding primary anilines.

引用

页码：841 / 845

页数：5

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