Investigating the role of FOXA1 protein in cancer

被引：0
|
作者：
Theodorou, I. [1 ]
Bahrami, A. [1 ,2 ]
Albrecht, T. [1 ]
Lam, E. W-F. [2 ]
机构：
[1] Imperial Coll London, Dept Chem, South Kensington Campus, London SW7 2AZ, England
[2] Imperial Coll London, Dept Surg & Canc, London W12 0NN, England
来源：
NANOTECHNOLOGY 2011: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY, NSTI-NANOTECH 2011, VOL 3 | 2011年
关键词：
electrochemical STM; protein-DNA interaction; transcription regulation; SCANNING-TUNNELING-MICROSCOPY;
D O I：
暂无
中图分类号：
TE [石油、天然气工业]; TK [能源与动力工程];
学科分类号：
0807 ; 0820 ;
摘要：
The aim of this research project is the study of the FOXA1 protein, which has been related with breast cancer. The effect of FOXA1 on FOXC2 protein expression is studied with Western blotting. Additionally, the binding kinetics of FOXC2 protein with FOXA1 gene are investigated using Scanning Tunnelling Microscopy at the single-molecule level. The results of the project will extend the understanding in the role of FOXA1 in gene regulation, providing important information for the use of FOXA1 as a biomarker for breast cancer as well as the development of new treatment techniques.
引用
收藏
页码：375 / 378
页数：4
相关论文
共 50 条
  • [1] FOXA1 in prostate cancer
    Dong, Hui-Yu
    Ding, Lei
    Zhou, Tian-Ren
    Yan, Tao
    Li, Jie
    Liang, Chao
    ASIAN JOURNAL OF ANDROLOGY, 2023, 25 (03) : 287 - 295
  • [2] FOXA1 in breast cancer
    Nakshatri, Harikrishna
    Badve, Sunil
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2009, 11
  • [3] FOXA1 gene that plays an important role in ovarian cancer
    Jeon, Seob
    Lee, Taek Sang
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2024, 34 (SUPPL_3) : A226 - A226
  • [4] FOXA1 protein expression and survival of breast cancer patients
    Mohsin, Mohammed A.
    Zayed, Karrar S.
    JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS, 2022, 13 (03) : 422 - 426
  • [5] FOXA1 and breast cancer risk
    Kerstin B Meyer
    Jason S Carroll
    Nature Genetics, 2012, 44 : 1176 - 1177
  • [6] FOXA1 and breast cancer risk
    Meyer, Kerstin B.
    Carroll, Jason S.
    NATURE GENETICS, 2012, 44 (11) : 1176 - 1177
  • [7] Investigating the role of FOXA1/2 & HNF4α in pancreatic ductal adenocarcinoma
    Orellana, Walter A.
    Gillis, Katherine
    Fang, Pengshu
    Fort, Gabriela
    Snyder, Eric L.
    CANCER RESEARCH, 2024, 84 (06)
  • [8] FOXA1 defines cancer cell specificity
    Zhang, Gaihua
    Zhao, Yongbing
    Liu, Yi
    Kao, Li-Pin
    Wang, Xiao
    Skerry, Benjamin
    Li, Zhaoyu
    SCIENCE ADVANCES, 2016, 2 (03):
  • [9] Expression of FOXA1 in breast cancer and the significance
    He, Weili
    Zhai, Hening
    Wang, Ningxia
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2019, 40 (01) : 97 - 100
  • [10] FOXA1 as a therapeutic target for breast cancer
    Nakshatri, Harikrishna
    Badve, Sunil
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (04) : 507 - 514
12345