Thrombotic arteriopathy and anticoagulation in pulmonary hypertension

被引：114
作者：
Johnson, Sindhu R.
Granton, John T.
Mehta, Sanjay
机构：
[1] Univ Toronto, Univ Hlth Network, Div Rheumatol, Toronto, ON, Canada
[2] Univ Toronto, Univ Hlth Network, Pulm Hypertens Ctr, Toronto, ON, Canada
[3] London Hlth Sci Ctr, Div Respirol, Lawson Hlth Res Inst, Ctr Crit Illness Res, London, ON, Canada
来源：
CHEST | 2006年 / 130卷 / 02期
关键词：
idiopathic pulmonary arterial hypertension; pulmonary hypertension; thrombosis; thrombotic arteriopathy;
D O I：
10.1016/S0012-3692(15)51873-4
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The role of thrombotic arteriopathy in the pathophysiology of idiopathic pulmonary arterial hypertension (IPAH) and the use of anticoagulants in the treatment of IPAH are currently controversial issues. This article reviews the evidence for a role of vascular thrombosis in the pathophysiology of IPAH. There is sufficient biological rationale to support the notion that thrombotic arteriopathy is an important pathophysiologic feature of pulmonary arterial hypertension (PAH) and that its progression materially contributes to disease progression. To date, the data from observational studies suggest that anticoagulation with warfarin is an effective intervention in patients with IPAH. Its efficacy in other causes of PAH remains speculative.
引用
收藏
页码：545 / 552
页数：8
相关论文
共 50 条
  • [1] THE PRIMARY ANTIPHOSPHOLIPID SYNDROME - MAJOR CLINICAL AND SEROLOGICAL FEATURES
    ASHERSON, RA
    KHAMASHTA, MA
    ORDIROS, J
    DERKSEN, RHWM
    MACHIN, SJ
    BARQUINERO, J
    OUTT, HH
    HARRIS, EN
    VILARDELLTORRES, M
    HUGHES, GRV
    [J]. MEDICINE, 1989, 68 (06) : 366 - 374
  • [2] ASHERSON RA, 1990, J RHEUMATOL, V17, P1292
  • [3] Medical therapy for pulmonary arterial hypertension - ACCP evidence-based clinical practice guidelines
    Badesch, DB
    Abman, SH
    Ahearn, GS
    Barst, RJ
    McCrory, DC
    Simonneau, G
    McLaughlin, VV
    [J]. CHEST, 2004, 126 (01) : 35S - 62S
  • [4] A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    Barst, RJ
    Rubin, LJ
    Long, WA
    McGoon, MD
    Rich, S
    Badesch, DB
    Groves, BM
    Tapson, VF
    Bourge, RC
    Brundage, BH
    Koerner, SK
    Langleben, D
    Keller, CA
    Murali, S
    Uretsky, BF
    Clayton, LM
    Jobsis, MM
    Blackburn, SD
    Shortino, D
    Crow, JW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) : 296 - 301
  • [5] SURVIVAL IN PRIMARY PULMONARY-HYPERTENSION WITH LONG-TERM CONTINUOUS INTRAVENOUS PROSTACYCLIN
    BARST, RJ
    RUBIN, LJ
    MCGOON, MD
    CALDWELL, EJ
    LONG, WA
    LEVY, PS
    [J]. ANNALS OF INTERNAL MEDICINE, 1994, 121 (06) : 409 - 415
  • [6] PRIMARY PULMONARY-HYPERTENSION - A HISTOPATHOLOGIC STUDY OF 80 CASES
    BJORNSSON, J
    EDWARDS, WD
    [J]. MAYO CLINIC PROCEEDINGS, 1985, 60 (01) : 16 - 25
  • [7] BOYERNEUMANN C, 1995, THROMB HAEMOSTASIS, V73, P735
  • [8] The role of thrombosis in severe pulmonary hypertension
    Chaouat, A
    Weitzenblum, E
    Higenbottam, T
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (02) : 356 - 363
  • [9] AN IMBALANCE BETWEEN THE EXCRETION OF THROMBOXANE AND PROSTACYCLIN METABOLITES IN PULMONARY-HYPERTENSION
    CHRISTMAN, BW
    MCPHERSON, CD
    NEWMAN, JH
    KING, GA
    BERNARD, GR
    GROVES, BM
    LOYD, JE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (02) : 70 - 75
  • [10] Gastrointestinal hemorrhage in patients with systemic sclerosis and CREST syndrome
    Duchini, A
    Sessoms, SL
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (09) : 1453 - 1456
12345