Asymmetric Transfer Hydrogenation of rac-α-(Purin-9-yl)cyclopentones via Dynamic Kinetic Resolution for the Construction of Carbocyclic Nucleosides

被引：24

作者：

Zhang, Yi-Ming ^{[1
]}

Zhang, Qi-Ying ^{[1
]}

Wang, Dong-Chao ^{[1
]}

Xie, Ming-Sheng ^{[1
]}

Qu, Gui-Rong ^{[1
]}

Guo, Hai-Ming ^{[1
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henan Key Lab Organ Funct Molecules & Drug Innova, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 09期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE SYNTHESIS; KETONES; ACCESS; DRIVEN; STEP;

D O I：

10.1021/acs.orglett.9b00451

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric transfer hydrogenation via dynamic kinetic resolution of a broad range of rac-alpha-(purin-9-yl)cyclopentones was first developed. A series of cis-beta-(purin-9-yl)cyclopentanols were obtained with up to 97% yield, >20/1 dr, and >99% ee. This also provides an efficient synthetic route to a variety of chiral carbocyclic nucleosides.

引用

页码：2998 / 3002

页数：5

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