diRNA-Ago2-RAD51 complexes at double-strand break sites

被引：9

作者：

Yamanaka, Soichiro ^{[1
]}

Siomi, Haruhiko ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Mol Biol, Tokyo 1608582, Japan

来源：

CELL RESEARCH | 2014年 / 24卷 / 05期

关键词：

DNA-DAMAGE RESPONSE; REPAIR; RNAS;

D O I：

10.1038/cr.2014.45

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully elucidated. Now, Gao et al. reveal that diRNA-Ago2 complexes recruit RAD51 to the break sites.

引用

页码：511 / 512

页数：2

共 12 条

[1] A direct role for small non-coding RNAs in DNA damage response [J].

di Fagagna, Fabrizio d'Adda .

TRENDS IN CELL BIOLOGY, 2014, 24 (03) :171-178

[2] Single-molecule imaging brings Rad51 nucleoprotein filaments into focus [J].

Forget, Anthony L. ;

Kowalczykowski, Stephen C. .

TRENDS IN CELL BIOLOGY, 2010, 20 (05) :269-276

[3] Site-specific DICER and DROSHA RNA products control the DNA-damage response [J].

Francia, Sofia ;

Michelini, Flavia ;

Saxena, Alka ;

Tang, Dave ;

de Hoon, Michiel ;

Anelli, Viviana ;

Mione, Marina ;

Carninci, Piero ;

di Fagagna, Fabrizio d'Adda .

NATURE, 2012, 488 (7410) :231-+

[4] Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination [J].

Gao, Min ;

Wei, Wei ;

Li, Ming-Ming ;

Wu, Yong-Sheng ;

Ba, Zhaoqing ;

Jin, Kang-Xuan ;

Li, Miao-Miao ;

Liao, You-Qi ;

Adhikari, Samir ;

Chong, Zechen ;

Zhang, Ting ;

Guo, Cai-Xia ;

Tang, Tie-shan ;

Zhu, Bing-Tao ;

Xu, Xing-Zhi ;

Mailand, Niels ;

Yang, Yun-Gui ;

Qi, Yijun ;

Danielsen, Jannie M. Rendtlew .

CELL RESEARCH, 2014, 24 (05) :532-541

[5] The DNA-damage response in human biology and disease [J].

Jackson, Stephen P. ;

Bartek, Jiri .

NATURE, 2009, 461 (7267) :1071-1078

[6] Homologous recombination and its regulation [J].

Krejci, Lumir ;

Altmannova, Veronika ;

Spirek, Mario ;

Zhao, Xiaolan .

NUCLEIC ACIDS RESEARCH, 2012, 40 (13) :5795-5818

[7] qiRNA is a new type of small interfering RNA induced by DNA damage [J].

Lee, Heng-Chi ;

Chang, Shwu-Shin ;

Choudhary, Swati ;

Aalto, Antti P. ;

Maiti, Mekhala ;

Bamford, Dennis H. ;

Liu, Yi .

NATURE, 2009, 459 (7244) :274-U163

[8] A small RNA response at DNA ends in Drosophila [J].

Michalik, Katharina M. ;

Boettcher, Romy ;

Foerstemann, Klaus .

NUCLEIC ACIDS RESEARCH, 2012, 40 (19) :9596-9603

[9] XRCC3 promotes homology-directed repair of DNA damage in mammalian cells [J].

Pierce, AJ ;

Johnson, RD ;

Thompson, LH ;

Jasin, M .

GENES & DEVELOPMENT, 1999, 13 (20) :2633-2638

[10] Different means, same end - heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast [J].

Reyes-Turcu, Francisca E. ;

Grewal, Shiv I. S. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2012, 22 (02) :156-163

← 1 2 →