Chicoric acid suppresses BAFF expression in B lymphocytes by inhibiting NF-κB activity

被引：13

作者：

Chen, Lingxi ^{[1
]}

Huang, Gang ^{[1
]}

Gao, Min ^{[1
]}

Shen, Xiaodong ^{[1
]}

Gong, Wei ^{[1
]}

Xu, Zhizhen ^{[1
]}

Zeng, Yijun ^{[1
]}

He, Fengtian ^{[1
]}

机构：

[1] Third Mil Med Univ, Dept Biochem & Mol Biol, Coll Basic Med Sci, Chongqing 400038, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2017年 / 44卷

基金：

中国国家自然科学基金;

关键词：

Chicoric acid; B cell activating factor belonging to the TNF family; NF-kappa B; Autoimmune diseases; COLLAGEN-INDUCED ARTHRITIS; NECROSIS-FACTOR FAMILY; ECHINACEA-PURPUREA; HEPATIC STEATOSIS; IN-VITRO; CELL; BLYS; CURCUMIN; EXTRACT;

D O I：

10.1016/j.intimp.2017.01.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell activating factor belonging to the TNF family (BAFF) plays a critical role in the pathogenesis of autoimmune diseases. The inhibition of BAFF expression is an emerging therapeutic approach for these disorders. Chicoric acid (CA), a bioactive phytochemical found in several widely used traditional medicinal plants, has significant anti-inflammatory activity and anti-arthritic effects. However, the role of CA in modulation of BAFF expression remains unknown. In this study, we demonstrated that CA reduced BAFF expression in human B lymphocyte cell lines and decreased the DNA-binding activity of nuclear factor-kappa B (NF-kappa B) in the BAFF promoter region. Furthermore, CA inhibited both the nuclear translocation of p65 (the subunit of NF-kappa B) and the phosphorylation of I kappa B alpha (inhibitor of NF-kappa B). These results suggest that CA suppresses BAFF expression by inhibiting NF-kappa B activity, and CA may serve as a novel therapeutic agent to down-regulate excessive BAFF expression in autoimmune diseases. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：211 / 215

页数：5

共 23 条

[1] Antihyperglycemic effect of a natural chicoric acid extract of chicory (Cichorium intybus L.): A comparative in vitro study with the effects of caffeic and ferulic acids [J].