Oxidative stress in Crohn's disease

被引：15

作者：

Moret, Ines ^{[1
,2
]}

Cerrillo, Elena ^{[1
,3
]}

Navarro-Puche, Ana ^{[1
]}

Iborra, Marisa ^{[2
]}

Rausell, Francisco ^{[1
,2
]}

Tortos, Luis ^{[1
,2
]}

Beltran, Belen ^{[2
,3
]}

机构：

[1] Inst Invest Sanitaria, Valencia, Spain

[2] CIBEREHD, Madrid, Spain

[3] Hosp Univ & Politecn La Fe, Serv Med Digest, Valencia, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2014年 / 37卷 / 01期

关键词：

Oxidative stress; Crohn's disease; Catalase; INFLAMMATORY-BOWEL-DISEASE; REACTIVE OXYGEN METABOLITES; NITRIC-OXIDE; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION; ULCERATIVE-COLITIS; DNA-DAMAGE; CELLS; PATHOGENESIS; INHIBITION;

D O I：

10.1016/j.gastrohep.2013.01.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.

引用

页码：28 / 34

页数：7

共 55 条

[11] Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine
Chiarpotto, E
Scavazza, A
Leonarduzzi, G
Camandola, S
Biasi, F
Teggia, PM
Garavoglia, M
Robecchi, A
Roncari, A
Poli, G
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (05) : 889 - 894
[12] Resistance to tumor necrosis factor-α (TNF-α)-induced apoptosis in rat hepatoma cells expressing TNF-α is linked to low antioxidant enzyme expression
Chovolou, Y
Watjen, W
Kampkotter, A
Kahl, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) : 29626 - 29632
[13] D'Odorico A, 2001, SCAND J GASTROENTERO, V36, P1289, DOI 10.1080/003655201317097146
[14] Dean RT, 1997, BIOCHEM J, V324, P1
[15] Oxidative DNA damage and antioxidant activity in patients with inflammatory bowel disease
Dincer, Yidiz
Erzin, Yusuf
Himmetoglu, Solen
Gunes, Kezban Nur
Bal, Kadir
Akcay, Tulay
[J]. DIGESTIVE DISEASES AND SCIENCES, 2007, 52 (07) : 1636 - 1641
[16] NF-κB activation by reactive oxygen species:: Fifteen years later
Gloire, Geoffrey
Legrand-Poels, Sylvie
Piette, Jacques
[J]. BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) : 1493 - 1505
[17] GUTTERIDGE JMC, 1995, CLIN CHEM, V41, P1819
[18] FREE-RADICALS AND OTHER REACTIVE OXYGEN METABOLITES IN INFLAMMATORY BOWEL-DISEASE - CAUSE, CONSEQUENCE OR EPIPHENOMENON
HARRIS, ML
SCHILLER, HJ
REILLY, PM
DONOWITZ, M
GRISHAM, MB
BULKLEY, GB
[J]. PHARMACOLOGY & THERAPEUTICS, 1992, 53 (03) : 375 - 408
[19] Redox regulation of signal transduction in mammalian cells
Herrlich, P
Böhmer, FD
[J]. BIOCHEMICAL PHARMACOLOGY, 2000, 59 (01) : 35 - 41
[20] Role of oxidative stress and antioxidant enzymes in Crohn's disease
Iborra, Marisa
Moret, Ines
Rausell, Francisco
Bastida, Guillermo
Aguas, Mariam
Cerrillo, Elena
Nos, Pilar
Beltran, Belen
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2011, 39 : 1102 - 1106

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