On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis

被引：149
作者：
Albericio, F
Cases, M
Alsina, J
Triolo, SA
Carpino, LA
Kates, SA
机构：
[1] UNIV MASSACHUSETTS,DEPT CHEM,AMHERST,MA 01003
[2] PERSEPT BIOSYST INC,FRAMINGHAM,MA 01701
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 27期
关键词：
D O I：
10.1016/S0040-4039(97)01011-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short sequences, and cyclic peptides. An advantage relative to uronium salts is that excess PyAOP does not undergo the detrimental side-reaction at the amino terminus which blocks further chain assembly. (C) 1997 Published by Elsevier Science Ltd.
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页码：4853 / 4856
页数：4
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