Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy

被引：34
作者：
Dickler, Adam [1 ]
Ivanov, Olga [2 ]
Francescatti, Darius [3 ]
机构：
[1] Little Co Mary Hosp, Dept Radiat Oncol, Evergreen Pk, IL 60805 USA
[2] Little Co Mary Hosp, Dept Gen Surg, Evergreen Pk, IL 60805 USA
[3] Rush Univ, Med Ctr, Dept Gen Surg, Chicago, IL 60612 USA
来源：
WORLD JOURNAL OF SURGICAL ONCOLOGY | 2009年 / 7卷
关键词：
20-YEAR FOLLOW-UP; CONSERVING SURGERY; RADIOTHERAPY TARGIT; IRRADIATION; TRIAL; MASTECTOMY; MANAGEMENT; RATES;
D O I：
10.1186/1477-7819-7-24
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an electronic source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery. Methods: We report on the first patient treated with XB to deliver IORT. Results: IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours. Conclusion: Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.
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页数：6
相关论文
共 19 条
[1]   Travel distance to radiation therapy and receipt of radiotherapy following breast-conserving surgery [J].
Athas, WF ;
Adams-Cameron, M ;
Hung, WC ;
Amir-Fazli, A ;
Key, CR .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (03) :269-271
[2]   Five-year results: the initial clinical trial of mammosite balloon brachytherapy for partial breast irradiation in early-stage breast cancer [J].
Benitez, Pamela R. ;
Keisch, Martin E. ;
Vicini, Frank ;
Stolier, Alan ;
Scroggins, Troy ;
Walker, Alonzo ;
White, Julia ;
Hedberg, Peter ;
Hebert, Mary ;
Arthur, Doug ;
Zannis, Vic ;
Quiet, Coral ;
Streeter, Oscar ;
Silverstein, Mel .
AMERICAN JOURNAL OF SURGERY, 2007, 194 (04) :456-462
[3]  
Clarke M, 2005, LANCET, V366, P287
[4]   A dosimetric comparison of MammoSite high-dose-rate brachytherapy and Xoft Axxent electronic brachytherapy [J].
Dickler, Adam ;
Kirk, Michael C. ;
Seif, Neil ;
Griem, Katherine ;
Dowlatshahi, Kambiz ;
Francescatti, Darius ;
Abrams, Ross A. .
BRACHYTHERAPY, 2007, 6 (02) :164-168
[5]   Low use of breast conservation surgery in medically indigent populations [J].
Dolan, JT ;
Granchi, TS ;
Miller, CC ;
Brunicardi, FC .
AMERICAN JOURNAL OF SURGERY, 1999, 178 (06) :470-473
[6]   GEOGRAPHIC-VARIATION IN THE TREATMENT OF LOCALIZED BREAST-CANCER [J].
FARROW, DC ;
HUNT, WC ;
SAMET, JM .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (17) :1097-1101
[7]   Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer [J].
Fisher, B ;
Anderson, S ;
Bryant, J ;
Margolese, RG ;
Deutsch, M ;
Fisher, ER ;
Jeong, J ;
Wolmark, N .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (16) :1233-1241
[8]   Breast conservation rates - Barriers between tertiary care and community practice [J].
Hahn, CA ;
Marks, LB ;
Chen, DY ;
Lind, PA ;
Lind, HM ;
Prosnitz, LR .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 55 (05) :1196-1199
[9]   The TARGIT trial: targeted intraoperative radiation therapy versus conventional postoperative whole-breast radiotherapy after breast-conserving surgery for the management of early-stage invasive breast cancer (a trial update) [J].
Holmes, Dennis R. ;
Baum, Michael ;
Joseph, David .
AMERICAN JOURNAL OF SURGERY, 2007, 194 (04) :507-510
[10]   Surgical technique of intraoperative radiotherapy in conservative treatment of limited-stage breast cancer [J].
Intra, M ;
Gatti, G ;
Luini, A ;
Galimberti, V ;
Veronesi, P ;
Zurrida, S ;
Frasson, A ;
Ciocca, M ;
Orecchia, R ;
Veronesi, U .
ARCHIVES OF SURGERY, 2002, 137 (06) :737-740
12