Enhanced Production of Poly (γ-glutamic acid) from Bacillus licheniformis NCIM 2324 by Using Metabolic Precursors

被引：55

作者：

Bajaj, Ishwar B. ^{[1
]}

Singhal, Rekha S. ^{[1
]}

机构：

[1] Univ Mumbai, Food Engn & Technol Dept, Inst Chem Technol, Bombay 400019, Maharashtra, India

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2009年 / 159卷 / 01期

关键词：

Poly (gamma-glutamic acid); Fermentation; Bacillus licheniformis; Precursors; alpha-Ketoglutaric acid; POLY(GAMMA-GLUTAMIC ACID); POLY(GAMMA-D-GLUTAMYL) CAPSULE; SUBTILIS IF03335; AMMONIUM-SULFATE; CITRIC-ACID; BIOSYNTHESIS; MICROORGANISMS; OPTIMIZATION; CHEMISTRY;

D O I：

10.1007/s12010-008-8427-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present work was to study the effect of addition of different amino acids and tricarboxylic acid cycle intermediates as metabolic precursors on the production of poly (gamma-glutamic acid) (PGA) by Bacillus licheniformis NCIM 2324. A maximum yield of 35.75 g/l was obtained with the medium supplemented with 0.5 mM l-glutamine and 10 mM alpha-ketoglutaric acid as compared to 26.12 g/l PGA achieved with the control in the absence of metabolic precursors. Addition of precursors also enhanced the utilization of l-glutamic acid during fermentation.

引用

页码：133 / 141

页数：9

共 50 条

[31] Metabolic Engineering of Bacillus subtilis for the Production of Poly-γ-Glutamic Acid from Glycerol Feedstock
Pasotti, Lorenzo
Massaiu, Ilaria
Magni, Paolo
Calvio, Cinzia
FERMENTATION-BASEL, 2024, 10 (06):
[32] Application of statistical experimental methods to optimize production of poly(γ-glutamic acid) by Bacillus licheniformis CCRC 12826
Shih, IL
Van, YT
Chang, YN
ENZYME AND MICROBIAL TECHNOLOGY, 2002, 31 (03) : 213 - 220
[33] A new strategy for enhancement of poly-γ-glutamic acid production by multiple physicochemical stresses in Bacillus licheniformis
Wei, Xuetuan
Tian, Guangming
Ji, Zhixia
Chen, Shouwen
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2015, 90 (04) : 709 - 713
[34] Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis
Wei Xiaoyu
Yang Lijie
Wang Haiyan
Chen Zhen
Xu Yiyuan
Weng Yue
Cao Mingfeng
Li Qingbiao
He Ning
Frontiers of Chemical Science and Engineering, 2022, 16 (12) : 1751 - 1760
[35] Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis
Wei, Xiaoyu
Yang, Lijie
Wang, Haiyan
Chen, Zhen
Xu, Yiyuan
Weng, Yue
Cao, Mingfeng
Li, Qingbiao
He, Ning
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 2022, 16 (12) : 1751 - 1760
[36] Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis
Xiaoyu Wei
Lijie Yang
Haiyan Wang
Zhen Chen
Yiyuan Xu
Yue Weng
Mingfeng Cao
Qingbiao Li
Ning He
Frontiers of Chemical Science and Engineering, 2022, 16 : 1751 - 1760
[37] Metabolic Engineering of Aspartic Acid Supply Modules for Enhanced Production of Bacitracin in Bacillus licheniformis
Zhu, Jiang
Li, Lingfeng
Wu, Fei
Wu, Yuanxin
Wang, Zhi
Chen, Xiaobin
Li, Junhui
Cai, Dongbo
Chen, Shouwen
ACS SYNTHETIC BIOLOGY, 2021, 10 (09): : 2243 - 2251
[38] Sequential Optimization Approach for Enhanced Production of Poly(γ-Glutamic Acid) from Newly Isolated Bacillus subtilis
Bajaj, Ishwar B.
Singhal, Rekha S.
FOOD TECHNOLOGY AND BIOTECHNOLOGY, 2009, 47 (03) : 313 - 322
[39] Enhanced production of poly-γ-glutamic acid by a newly-isolated Bacillus subtilis
Wan-Taek Ju
Yong-Su Song
Woo-Jin Jung
Ro-Dong Park
Biotechnology Letters, 2014, 36 : 2319 - 2324
[40] Covalent modification in aqueous solution of poly-γ-D-glutamic acid from Bacillus licheniformis
King, EC
Watkins, WJ
Blacker, AJ
Bugg, TDH
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1998, 36 (12) : 1995 - 1999

← 1 2 3 4 5 →