C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress

被引：10
|
作者：
Bazhenova, Ekaterina Y. [1 ]
Bazovkina, Daria V. [2 ]
Kulikova, Elizabeth A. [2 ]
Fursenko, Dariya V. [1 ]
Khotskin, Nikita V. [1 ]
Lichman, Daria V. [3 ]
Kulikov, Alexander V. [1 ]
机构：
[1] Russian Acad Sci, Fed Res Ctr, Inst Cytol & Genet, Dept Genet Models Neuropathol,Siberian Div, Novosibirsk 630090, Russia
[2] Russian Acad Sci, Fed Res Ctr, Inst Cytol & Genet, Lab Behav Neurogen,Siberian Div, Novosibirsk 630090, Russia
[3] Russian Acad Sci, Fed Res Ctr, Inst Cytol & Genet, Lab Populat Ethnogenet,Siberian Div, Novosibirsk 630090, Russia
来源：
NEUROSCIENCE LETTERS | 2017年 / 640卷
基金：
俄罗斯基础研究基金会;
关键词：
Stress; Serotonin; Tryptophan hydroxylase-2 gene; C1473G polymorphism; Mice; HUMAN TRYPTOPHAN-HYDROXYLASE-2 GENE; RAT-BRAIN; TPH2; GENE; SEROTONIN; DEPRESSION; EXPRESSION; RESTRAINT; BEHAVIOR; ASSOCIATION; INVOLVEMENT;
D O I：
10.1016/j.neulet.2017.01.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurotransmitter serotonin (5-HT) is involved in the regulation of stress response. Tryptophan hydroxylase-2 (TPH2) is the key enzyme of serotonin (5-HT) synthesis in the brain. C1473G polymorphism in Tph2 gene is the main factor defining the enzyme activity in the brain of laboratory mice. The effect of interaction between C1473G polymorphism and 30 min restriction stress on the behavior in the open field test, c-Fos gene expression and 5-HT metabolism in the brain in adult male of B6-1473C and B6-1473G congenic mouse lines with high and low TPH2 activity was investigated. A significant effect of genotype x stress interaction on c-Fos mRNA in the hypothalamus (F-1,F-21 = 10.66, p < 0.001) and midbrain (F-1,F-21=9.18, p < 0.01) was observed. The stress-induced rise of c-Fos mRNA in these structures is more intensive in B6-1473G than in B6-1473C mice. A marked effect of genotype x stress interaction on 5-HT level in the cortex (F-1,F-18 = 9.38, p < 0.01) and 5-HIAA/5-HT turnover rate in the hypothalamus (F-1,F-18 = 9.01, p < 0.01) was revealed. The restriction significantly decreased 5-HT level in the cortex (p < 0.01) and increased 5HIAA/5-HT rate (p < 0.001) in the hypothalamus in B6-1473C mice, but not in B6-1473G mice. The present result is the first experimental evidence that C1473G polymorphism is involved in the regulation of the reaction to emotional stress in mice. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 110
页数：6
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