SUCCESSFUL TREATMENT OF DISSEMINATED INVASIVE MYCOSIS CAUSED BY SAPROCHAETE CAPITATA IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA

The case report of a rare disseminated invasive mycosis due to Saprochaete capitata in a patient with acute lymphoblastic leukemia (ALL). The main risk factors were prolonged granulocytopenia for 21 days, presence of a central venous catheter (CVC), refractory form of ALL. S. capitata was isolated from blood cultures and CVC. Invasive mycosis due to S. capitate developed in patient receiving echinocandin for 5 days and was represented by septic shock at the onset, early dissemination in the organs (liver, spleen, kidney), prolonged fever for 167 days. Clinical improvement was achieved by using the combination of voriconazole with amphotericin B and removing of CVC. Total duration of voriconazole treatment was more than 200 days, of those 101 days in combination with amphotericin B. ALL treatment was continued with concomitant voriconazole therapy after improvement of patient condition. Relapse of invasive mycosis did not occur.