The biological pathways of Alzheimer disease: a review

被引：156

作者：

Calabro, Marco ^{[1
]}

Rinaldi, Carmela ^{[1
]}

Santoro, Giuseppe ^{[1
]}

Crisafulli, Concetta ^{[1
]}

机构：

[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

来源：

AIMS NEUROSCIENCE | 2021年 / 8卷 / 01期

关键词：

Alzheimer disease; biological pathways; immune system; oxidative stress; AMYLOID-BETA-PEPTIDE; GENOME-WIDE ASSOCIATION; BRAIN INSULIN-RESISTANCE; LONG-TERM POTENTIATION; APOLIPOPROTEIN-E; A-BETA; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; CEREBRAL HYPOPERFUSION; DIAGNOSTIC GUIDELINES;

D O I：

10.3934/Neuroscience.2021005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with beta-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.

引用

页码：86 / 132

页数：47

共 424 条

[61] Forecasting the global burden of Alzheimer's disease [J].

Brookmeyer, Ron ;

Johnson, Elizabeth ;

Ziegler-Graham, Kathryn ;

Arrighi, H. Michael .

ALZHEIMERS & DEMENTIA, 2007, 3 (03) :186-191

[62] Contribution of TARDBP to Alzheimer's Disease Genetic Etiology [J].

Brouwers, Nathalie ;

Bettens, Karolien ;

Gijselinck, Ilse ;

Engelborghs, Sebastiaan ;

Pickut, Barbara A. ;

Van Miegroet, Helen ;

Montoya, Ana Gil ;

Mattheijssens, Maria ;

Peeters, Karin ;

De Deyn, Peter P. ;

Cruts, Marc ;

Sleegers, Kristel ;

Van Broeckhoven, Christine .

JOURNAL OF ALZHEIMERS DISEASE, 2010, 21 (02) :423-430

[63] Cognitive impairment in humanized APP x PS1 mice is linked to Aβ1-42 and NOX activation [J].

Bruce-Keller, Annadora J. ;

Gupta, Sunita ;

Knight, Alecia G. ;

Beckett, Tina L. ;

McMullen, Jessica M. ;

Davis, Paulina R. ;

Murphy, M. Paul ;

Van Eldik, Linda J. ;

St Clair, Daret ;

Keller, Jeffrey N. .

NEUROBIOLOGY OF DISEASE, 2011, 44 (03) :317-326

[64] Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications [J].

Bubber, P ;

Haroutunian, V ;

Fisch, G ;

Blass, JP ;

Gibson, GE .

ANNALS OF NEUROLOGY, 2005, 57 (05) :695-703

[65] Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease [J].

Butterfield, D. Allan ;

Lange, Miranda L. Bader ;

Sultana, Rukhsana .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2010, 1801 (08) :924-929

[66] Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature [J].

Caccamo, Antonella ;

De Pinto, Vito ;

Messina, Angela ;

Branca, Caterina ;

Oddo, Salvatore .

JOURNAL OF NEUROSCIENCE, 2014, 34 (23) :7988-7998

[67] Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism [J].

Caccamo, Antonella ;

Maldonado, Monica A. ;

Majumder, Smita ;

Medina, David X. ;

Holbein, Walter ;

Magri, Andrea ;

Oddo, Salvatore .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (11) :8924-8932

[68] Mitochondrial reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors and induce long-term depression of fast nicotinic synaptic transmission [J].

Campanucci, Veronica A. ;

Krishnaswamy, Arjun ;

Cooper, Ellis .

JOURNAL OF NEUROSCIENCE, 2008, 28 (07) :1733-1744

[69] Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a Crucial Factor in Both Pathologies? [J].

Campos-Pena, Victoria ;

Toral-Rios, Danira ;

Becerril-Perez, Fernando ;

Sanchez-Torres, Carmen ;

Delgado-Namorado, Yair ;

Torres-Ossorio, Elimar ;

Franco-Bocanegra, Diana ;

Carvajal, Karla .

ANTIOXIDANTS & REDOX SIGNALING, 2017, 26 (10) :542-+

[70] Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression [J].

Carden, Trevor ;

Singh, Bhupendra ;

Mooga, Ved ;

Bajpai, Prachi ;

Singh, Keshav K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (50) :20694-20706

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