The biological pathways of Alzheimer disease: a review

被引：160

作者：

Calabro, Marco ^{[1
]}

Rinaldi, Carmela ^{[1
]}

Santoro, Giuseppe ^{[1
]}

Crisafulli, Concetta ^{[1
]}

机构：

[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

来源：

AIMS NEUROSCIENCE | 2021年 / 8卷 / 01期

关键词：

Alzheimer disease; biological pathways; immune system; oxidative stress; AMYLOID-BETA-PEPTIDE; GENOME-WIDE ASSOCIATION; BRAIN INSULIN-RESISTANCE; LONG-TERM POTENTIATION; APOLIPOPROTEIN-E; A-BETA; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; CEREBRAL HYPOPERFUSION; DIAGNOSTIC GUIDELINES;

D O I：

10.3934/Neuroscience.2021005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with beta-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.

引用

页码：86 / 132

页数：47

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