Epigenetics and Cardiovascular Disease in Diabetes

被引：30

作者：

Pasquier, Jennifer ^{[1
,2
]}

Hoarau-Vechot, Jessica ^{[2
]}

Fakhro, Khalid ^{[2
,3
]}

Rafii, Arash ^{[1
,4
]}

Khalil, Charbel Abi ^{[2
,4
,5
,6
]}

机构：

[1] Weill Cornell Med Coll, Stem Cell & Microenvironm Lab, Doha, Qatar

[2] Weill Cornell Med Coll, Dept Med Genet, Cardiovasc Epigenet Lab, Doha, Qatar

[3] Sidra Med & Res Ctr, Doha, Qatar

[4] Weill Cornell Med Coll, Dept Med Genet, New York, NY USA

[5] Weill Cornell Med Coll, Dept Med, New York, NY USA

[6] Weill Cornell Med Coll, Dept Med, Doha, Qatar

来源：

CURRENT DIABETES REPORTS | 2015年 / 15卷 / 12期

关键词：

Epigenetics; Cardiovascular disease; Diabetes; Cardiovascular complications of diabetes; Macrovascular complications of diabetes; Diabetic cardiomyopathy; SMOOTH-MUSCLE-CELLS; DNA METHYLATION; GENE-EXPRESSION; HIGH GLUCOSE; CIRCULATING MICRORNAS; HISTONE MODIFICATIONS; COLLAGEN EXPRESSION; ENDOTHELIAL-CELLS; METABOLIC MEMORY; OXIDATIVE-STRESS;

D O I：

10.1007/s11892-015-0677-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes has become a major health issue worldwide. Chronic hyperglycemia induces a low-grade inflammation that, on top of other mechanisms, leads to endothelial dysfunction. Mounting evidence suggests that DNA methylation, post-translational modifications of histones, and long non-coding RNAs play an important role in the initiation, maintenance, and progression of both macro- and microvascular complications of diabetes. Long-term exposure to hyperglycemia induces epigenetic changes that could become irreversible, a phenomenon known as the 'metabolic memory.' Whether epigenetic-based therapies could be used to slow or limit the progression of cardiovascular disease remains unclear. While non-coding RNAs are currently investigated as potential biomarkers that predict diabetic cardiovascular disease incidence and progression, their therapeutic role is only hypothetical. In this review, we highlight the latest findings in experimental and clinical studies relevant to epigenetics and cardiovascular disease in diabetes.

引用

页数：12

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