Flumazenil positron emission tomography and other ligands for functional imaging

被引：25
作者：
Hammers, A
机构：
[1] UCL, Dept Clin & Expt Epilepsy, Inst Neurol, London WC1N 3BG, England
[2] Univ London Imperial Coll Sci & Technol, Dept PET Neurosci, MRC Clin Sci Ctr, London W12 0NN, England
来源：
NEUROIMAGING CLINICS OF NORTH AMERICA | 2004年 / 14卷 / 03期
关键词：
D O I：
10.1016/j.nic.2004.04.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Positron emission tomography (PET) enables tomographic imaging of local concentrations of injected biologically active substances that have been radioactively labeled (radioligands; tracers). Patients can be investigated in the resting state or in relationship to an event (eg, injection of a drug or occurrence of a seizure). This article discusses the use of flumazenil PET and other ligands in focal and idiopathic generalized epilepsies.
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页码：537 / +
页数：16
相关论文
共 96 条
[31]   QUANTIFYING INTERICTAL METABOLIC-ACTIVITY IN HUMAN TEMPORAL-LOBE EPILEPSY [J].
HENRY, TR ;
MAZZIOTTA, JC ;
ENGEL, J ;
CHRISTENSON, PD ;
ZHANG, JX ;
PHELPS, ME ;
KUHL, DE .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (05) :748-757
[32]   IN-VIVO CEREBRAL METABOLISM AND CENTRAL BENZODIAZEPINE-RECEPTOR BINDING IN TEMPORAL-LOBE EPILEPSY [J].
HENRY, TR ;
FREY, KA ;
SACKELLARES, JC ;
GILMAN, S ;
KOEPPE, RA ;
BRUNBERG, JA ;
ROSS, DA ;
BERENT, S ;
YOUNG, AB ;
KUHL, DE .
NEUROLOGY, 1993, 43 (10) :1998-2006
[33]   QUANTITATION IN POSITRON EMISSION COMPUTED-TOMOGRAPHY .1. EFFECT OF OBJECT SIZE [J].
HOFFMAN, EJ ;
HUANG, SC ;
PHELPS, ME .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1979, 3 (03) :299-308
[34]   DIFFERENTIATION OF RADIOLIGAND DELIVERY AND BINDING IN THE BRAIN - VALIDATION OF A 2-COMPARTMENT MODEL FOR [C-11] FLUMAZENIL [J].
HOLTHOFF, VA ;
KOEPPE, RA ;
FREY, KA ;
PARADISE, AH ;
KUHL, DE .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (05) :745-752
[35]   CENTRAL AND PERIPHERAL BENZODIAZEPINE RECEPTORS - OPPOSITE CHANGES IN HUMAN EPILEPTOGENIC TISSUE [J].
JOHNSON, EW ;
DELANEROLLE, NC ;
KIM, JH ;
SUNDARESAN, S ;
SPENCER, DD ;
MATTSON, RH ;
ZOGHBI, SS ;
BALDWIN, RM ;
HOFFER, PB ;
SEIBYL, JP ;
INNIS, RB .
NEUROLOGY, 1992, 42 (04) :811-815
[36]   Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy [J].
Juhász, C ;
Chugani, DC ;
Muzik, O ;
Watson, C ;
Shah, J ;
Shah, A ;
Chugani, HT .
NEUROLOGY, 2000, 55 (06) :825-834
[37]   Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy [J].
Juhász, C ;
Chugani, DC ;
Muzik, O ;
Shah, A ;
Asano, E ;
Mangner, TJ ;
Chakraborty, PK ;
Sood, S ;
Chugani, HT .
NEUROLOGY, 2003, 60 (06) :960-968
[38]   Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome [J].
Juhász, C ;
Chugani, DC ;
Muzik, O ;
Shah, A ;
Shah, J ;
Watson, C ;
Canady, A ;
Chugani, HT .
NEUROLOGY, 2001, 56 (12) :1650-1658
[39]   MRI and PET coregistration - A cross validation of statistical parametric mapping and automated image registration [J].
Kiebel, SJ ;
Ashburner, J ;
Poline, JB ;
Friston, KJ .
NEUROIMAGE, 1997, 5 (04) :271-279
[40]   In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy [J].
Knowlton, RC ;
Laxer, KD ;
Klein, G ;
Sawrie, S ;
Ende, G ;
Hawkins, RA ;
Aassar, OS ;
Soohoo, K ;
Wong, S ;
Barbaro, N .
NEUROLOGY, 2001, 57 (07) :1184-1190
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