Flumazenil positron emission tomography and other ligands for functional imaging

被引：25
作者：
Hammers, A
机构：
[1] UCL, Dept Clin & Expt Epilepsy, Inst Neurol, London WC1N 3BG, England
[2] Univ London Imperial Coll Sci & Technol, Dept PET Neurosci, MRC Clin Sci Ctr, London W12 0NN, England
来源：
NEUROIMAGING CLINICS OF NORTH AMERICA | 2004年 / 14卷 / 03期
关键词：
D O I：
10.1016/j.nic.2004.04.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Positron emission tomography (PET) enables tomographic imaging of local concentrations of injected biologically active substances that have been radioactively labeled (radioligands; tracers). Patients can be investigated in the resting state or in relationship to an event (eg, injection of a drug or occurrence of a seizure). This article discusses the use of flumazenil PET and other ligands in focal and idiopathic generalized epilepsies.
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页码：537 / +
页数：16
相关论文
共 96 条
[21]   MU-OPIATE RECEPTORS MEASURED BY POSITRON EMISSION TOMOGRAPHY ARE INCREASED IN TEMPORAL-LOBE EPILEPSY [J].
FROST, JJ ;
MAYBERG, HS ;
FISHER, RS ;
DOUGLASS, KH ;
DANNALS, RF ;
LINKS, JM ;
WILSON, AA ;
RAVERT, HT ;
ROSENBAUM, AE ;
SNYDER, SH ;
WAGNER, HN .
ANNALS OF NEUROLOGY, 1988, 23 (03) :231-237
[22]   Imaging cerebral vasculitis in refractory epilepsy using [11C](R)-PK11195 positron emission tomography [J].
Goerres, GW ;
Revesz, T ;
Duncan, J ;
Banati, RB .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2001, 176 (04) :1016-1018
[23]   Parametric imaging of ligand-receptor binding in PET using a simplified reference region model [J].
Gunn, RN ;
Lammertsma, AA ;
Hume, SP ;
Cunningham, VJ .
NEUROIMAGE, 1997, 6 (04) :279-287
[24]   MESIOBASAL VERSUS LATERAL TEMPORAL-LOBE EPILEPSY - METABOLIC DIFFERENCES IN THE TEMPORAL-LOBE SHOWN BY INTERICTAL F-18 FDG POSITRON EMISSION TOMOGRAPHY [J].
HAJEK, M ;
ANTONINI, A ;
LEENDERS, KL ;
WIESER, HG .
NEUROLOGY, 1993, 43 (01) :79-86
[25]   Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients [J].
Hammers, A ;
Koepp, MJ ;
Richardson, MP ;
Hurlemann, R ;
Brooks, DJ ;
Duncan, JS .
BRAIN, 2003, 126 :1300-1318
[26]   Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI [J].
Hammers, A ;
Koepp, MJ ;
Hurlemann, R ;
Thom, M ;
Richardson, MP ;
Brooks, DJ ;
Duncan, JS .
BRAIN, 2002, 125 :2257-2271
[27]   Central benzodiazepine receptors in malformations of cortical development -: A quantitative study [J].
Hammers, A ;
Koepp, MJ ;
Richardson, MP ;
Labbé, C ;
Brooks, DJ ;
Cunningham, VJ ;
Duncan, JS .
BRAIN, 2001, 124 :1555-1565
[28]   Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy [J].
Hammers, A ;
Koepp, M ;
Labbé, C ;
Brooks, DJ ;
Thom, M ;
Cunningham, VJ ;
Duncan, JS .
NEUROLOGY, 2001, 56 (07) :897-906
[29]  
Hammers Alexander, 2001, Epilepsia, V42, P100
[30]   Central benzodiazepine receptor autoradiography in hippocampal sclerosis [J].
Hand, KSP ;
Baird, VH ;
VanPaesschen, W ;
Koepp, MJ ;
Revesz, T ;
Thom, M ;
Harkness, WFJ ;
Duncan, JS ;
Bowery, NG .
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 122 (02) :358-364
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